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- W1987400382 abstract "Objective The aim of this study was to evaluate whether differentHelicobacter pylorigenotypes are associated with different clinical stages of peptic ulcer disease (PUD). Design We assessed the virulence characteristics ofH. pyloriisolates from patients with active PUD (presence of an ulcer crater at endoscopy) and from those with PUD in remission (normal endoscopic findings or scar not induced by drugs in PUD patients). Methods H. pyloriisolates from biopsies of the gastric antrum were examined forcagAandvacAgenotypes by PCR amplification and Western blot analysis. Descriptive statistical techniques and multivariate polytomous logistic regression were used to estimate adjusted odds ratio (OR) forcagAandvacAgenotypes in patients with active PUD or PUD in remission. Patients with non-ulcer dyspepsia (NUD) were used as negative controls. Results ThecagAgenotype and phenotype were found to be differently associated with disease status. In fact, the multivariate regression model showed that gastric colonization by CagA+H. pyloristrains was associated with an increased risk of active PUD (OR 2.58), whereas the OR for patients with PUD in remission was 0.94. Conclusions Our data indicate that the active ulcer status is more strongly associated withH. pyloristrains carrying the pathogenicity island (PAI) than remission status. These results support the hypothesis that a dynamic equilibrium exists among bacterial populations with or without the PAI, and that the relapse of the peptic ulcer could be consequent to expansion of theH. pyloripopulation carrying the PAI." @default.
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- W1987400382 date "2000-11-01" @default.
- W1987400382 modified "2023-09-23" @default.
- W1987400382 title "Cytotoxin-associated gene A and vacuolating cytotoxin A in human isolates of Helicobacter pylori and their association with the clinical status of ulcer disease" @default.
- W1987400382 doi "https://doi.org/10.1097/00042737-200012110-00007" @default.
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