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- W1987407561 endingPage "2605" @default.
- W1987407561 startingPage "2596" @default.
- W1987407561 abstract "Until recently, immunotherapy for melanoma has made only small incremental improvements since the first attempts to treat patients with high-dose IL-2. Vaccination strategies alone have shown little efficacy, whereas attempts to boost the endogenous host antitumor response with agents such as anti-CTLA4 have met with marginal success. In the case of the latter agent, clinical efficacy in shrinking tumors has often come at a high price in terms of autoimmune toxicities that have been potentially life threatening. By contrast, ACT therapy, particularly following lymphodepleting, preconditioning regimen has resulted in response rates approaching 50%. Lymphodepletion appears to be particularly critical for the success of these therapies because (1) it provides access to cytokines that promote growth and survival of newly transferred T cells and (2) it removes suppressive or regulatory T-cell populations." @default.
- W1987407561 created "2016-06-24" @default.
- W1987407561 creator A5041804592 @default.
- W1987407561 creator A5045346465 @default.
- W1987407561 creator A5080283192 @default.
- W1987407561 date "2008-11-01" @default.
- W1987407561 modified "2023-10-02" @default.
- W1987407561 title "Immunotherapy for Advanced Melanoma" @default.
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