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- W1987418608 abstract "This chapter examines the scientific rationale and the evidence for Passive antibody immunotherapy (PAI) for cryptosporidiosis including practical considerations and future approaches. PAI for cryptosporidiosis is a treatment strategy that has been actively pursued in laboratory studies and early-stage clinical studies for the past decade. Several experimental approaches have been initiated, including the use of bovine colostrum and colostral antibodies, monoclonal antibodies, chicken egg yolk antibodies, and even orally administered human plasma antibodies. Most studies have employed oral administration to treat or prevent this intestinal infection. The interest in this treatment strategy has been sparked by the lack of an effective or approved therapy, increased awareness of the widespread nature of this parasite, epidemiological evidence that humoral immunity plays an important role in host resistance, and several early case reports of antibody therapy in which remarkable resolution of the disease is observed. However, most studies using a variety of preparations of antibodies administered to animals and humans have shown some degree of efficacy, though the responses have been, for the most part, partial rather than complete resolution of the disease." @default.
- W1987418608 created "2016-06-24" @default.
- W1987418608 creator A5047989703 @default.
- W1987418608 date "1998-01-01" @default.
- W1987418608 modified "2023-09-23" @default.
- W1987418608 title "Antibody-based Immunotherapy of Cryptosporidiosis" @default.
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- W1987418608 doi "https://doi.org/10.1016/s0065-308x(08)60119-0" @default.
- W1987418608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9554072" @default.
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