FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987433340> ?p ?o ?g. }

• W1987433340 endingPage "865" @default.
• W1987433340 startingPage "854" @default.
• W1987433340 abstract "The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, OAS1, and IL-6 after influenza virus infection. Consistent with increased inflammation, Nlrx1(-/-) mice exhibited marked morbidity and histopathology. Infection of these mice with an influenza strain that carries a mutated NS-1 protein, which normally prevents IFN induction by interaction with RNA and the intracellular RNA sensor RIG-I, further exacerbated IL-6 and type I IFN signaling. NLRX1 also weakened cytokine responses to the 2009 H1N1 pandemic influenza virus in human cells. Mechanistically, Nlrx1 deletion led to constitutive interaction of MAVS and RIG-I. Additionally, an inhibitory function is identified for NLRX1 during LPS activation of macrophages where the MAVS-RIG-I pathway was not involved. NLRX1 interacts with TRAF6 and inhibits NF-κB activation. Thus, NLRX1 functions as a checkpoint of overzealous inflammation." @default.
• W1987433340 created "2016-06-24" @default.
• W1987433340 creator A5005881707 @default.
• W1987433340 creator A5007340248 @default.
• W1987433340 creator A5008179003 @default.
• W1987433340 creator A5009651009 @default.
• W1987433340 creator A5010891569 @default.
• W1987433340 creator A5012090861 @default.
• W1987433340 creator A5018254763 @default.
• W1987433340 creator A5019419731 @default.
• W1987433340 creator A5033538044 @default.
• W1987433340 creator A5041958759 @default.
• W1987433340 creator A5046975725 @default.
• W1987433340 creator A5051886550 @default.
• W1987433340 creator A5059396334 @default.
• W1987433340 creator A5064572317 @default.
• W1987433340 creator A5079122448 @default.
• W1987433340 date "2011-06-01" @default.
• W1987433340 modified "2023-10-13" @default.
• W1987433340 title "NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways" @default.
• W1987433340 cites W1536422556 @default.
• W1987433340 cites W1771524005 @default.
• W1987433340 cites W1932202918 @default.
• W1987433340 cites W1952767463 @default.
• W1987433340 cites W1970154782 @default.
• W1987433340 cites W1975296966 @default.
• W1987433340 cites W1979849055 @default.
• W1987433340 cites W1983502509 @default.
• W1987433340 cites W1993728991 @default.
• W1987433340 cites W1994614818 @default.
• W1987433340 cites W2008332711 @default.
• W1987433340 cites W2009127910 @default.
• W1987433340 cites W2014960200 @default.
• W1987433340 cites W2028575270 @default.
• W1987433340 cites W2032980461 @default.
• W1987433340 cites W2039010779 @default.
• W1987433340 cites W2048562253 @default.
• W1987433340 cites W2060098032 @default.
• W1987433340 cites W2067262890 @default.
• W1987433340 cites W2080820947 @default.
• W1987433340 cites W2101028231 @default.
• W1987433340 cites W2107513655 @default.
• W1987433340 cites W2118317431 @default.
• W1987433340 cites W2127330186 @default.
• W1987433340 cites W2128847991 @default.
• W1987433340 cites W2133006561 @default.
• W1987433340 cites W2137303998 @default.
• W1987433340 cites W2138677670 @default.
• W1987433340 cites W2141425521 @default.
• W1987433340 cites W2144709035 @default.
• W1987433340 cites W2155752130 @default.
• W1987433340 cites W2161533969 @default.
• W1987433340 cites W2165655956 @default.
• W1987433340 doi "https://doi.org/10.1016/j.immuni.2011.03.026" @default.
• W1987433340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3166771" @default.
• W1987433340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21703540" @default.
• W1987433340 hasPublicationYear "2011" @default.
• W1987433340 type Work @default.
• W1987433340 sameAs 1987433340 @default.
• W1987433340 citedByCount "299" @default.
• W1987433340 countsByYear W19874333402012 @default.
• W1987433340 countsByYear W19874333402013 @default.
• W1987433340 countsByYear W19874333402014 @default.
• W1987433340 countsByYear W19874333402015 @default.
• W1987433340 countsByYear W19874333402016 @default.
• W1987433340 countsByYear W19874333402017 @default.
• W1987433340 countsByYear W19874333402018 @default.
• W1987433340 countsByYear W19874333402019 @default.
• W1987433340 countsByYear W19874333402020 @default.
• W1987433340 countsByYear W19874333402021 @default.
• W1987433340 countsByYear W19874333402022 @default.
• W1987433340 countsByYear W19874333402023 @default.
• W1987433340 crossrefType "journal-article" @default.
• W1987433340 hasAuthorship W1987433340A5005881707 @default.
• W1987433340 hasAuthorship W1987433340A5007340248 @default.
• W1987433340 hasAuthorship W1987433340A5008179003 @default.
• W1987433340 hasAuthorship W1987433340A5009651009 @default.
• W1987433340 hasAuthorship W1987433340A5010891569 @default.
• W1987433340 hasAuthorship W1987433340A5012090861 @default.
• W1987433340 hasAuthorship W1987433340A5018254763 @default.
• W1987433340 hasAuthorship W1987433340A5019419731 @default.
• W1987433340 hasAuthorship W1987433340A5033538044 @default.
• W1987433340 hasAuthorship W1987433340A5041958759 @default.
• W1987433340 hasAuthorship W1987433340A5046975725 @default.
• W1987433340 hasAuthorship W1987433340A5051886550 @default.
• W1987433340 hasAuthorship W1987433340A5059396334 @default.
• W1987433340 hasAuthorship W1987433340A5064572317 @default.
• W1987433340 hasAuthorship W1987433340A5079122448 @default.
• W1987433340 hasBestOaLocation W19874333401 @default.
• W1987433340 hasConcept C136449434 @default.
• W1987433340 hasConcept C159047783 @default.
• W1987433340 hasConcept C203014093 @default.
• W1987433340 hasConcept C2776914184 @default.
• W1987433340 hasConcept C62478195 @default.
• W1987433340 hasConcept C86803240 @default.
• W1987433340 hasConcept C8891405 @default.
• W1987433340 hasConcept C95444343 @default.
• W1987433340 hasConceptScore W1987433340C136449434 @default.

• next