FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987435105> ?p ?o ?g. }

• W1987435105 endingPage "648" @default.
• W1987435105 startingPage "639" @default.
• W1987435105 abstract "The neutral theory of molecular evolution (Kimura 1985) is the basis for most current statistical tests for detecting selection, mainly using polymorphism data within species, divergence data between species, and/or genomic structures like linkage disequilibrium (Wang et al. 2006). In most cases informative tests can only be constructed with ample variations within these parameters and many common tests are difficult to formulate when identity-by-descent is not clear, for example in gene families or repetitive elements. With the current progress being made toward whole-genome sequencing and re-sequencing efforts, as well as protein sequencing via tandem mass spectrometry where genomic sequencing is lacking, we felt it was necessary to re-visit possible methods for rapid screening and detection of evolutionary outliers. These outliers might be of interest for other research, such as candidate gene association studies or genome annotations, drug- and disease-target searches, and functional studies. We focused on methods that would work on both protein and nucleotide data, could be used on large gene or protein domain families, and could be generated quickly in order for first pass annotation of large scale data. For these reasons, we chose properties of trees generated routinely in molecular phylogenetic studies; genetic distance, tree shape and balance, and internal node statistics (Heard 1992). Our current research looking at protein domain family data and phylogenetic trees from PFAM (Finn et al. 2008) suggests this approach towards detecting evolutionary outliers is feasible, but additional work will be necessary to determine the parameters that suggest either positive or negative selection is occurring in specific gene families. This is particularly true when other factors such as rapid duplication and deletion of genes containing these domains is taking place, and we suggest phylogenetic statistics may be useful in combination with existing methodologies for detailed studies of gene family data." @default.
• W1987435105 created "2016-06-24" @default.
• W1987435105 creator A5031831796 @default.
• W1987435105 creator A5072779805 @default.
• W1987435105 date "2011-03-13" @default.
• W1987435105 modified "2023-09-26" @default.
• W1987435105 title "Detection of selection utilizing molecular phylogenetics: a possible approach" @default.
• W1987435105 cites W1576649281 @default.
• W1987435105 cites W1854335913 @default.
• W1987435105 cites W1973435014 @default.
• W1987435105 cites W1975245671 @default.
• W1987435105 cites W1980901426 @default.
• W1987435105 cites W2016000389 @default.
• W1987435105 cites W2016907728 @default.
• W1987435105 cites W2024172842 @default.
• W1987435105 cites W2026989517 @default.
• W1987435105 cites W2027932076 @default.
• W1987435105 cites W2028309288 @default.
• W1987435105 cites W2035002214 @default.
• W1987435105 cites W2038898901 @default.
• W1987435105 cites W2043708857 @default.
• W1987435105 cites W2048586339 @default.
• W1987435105 cites W2049888624 @default.
• W1987435105 cites W2052499864 @default.
• W1987435105 cites W2061097224 @default.
• W1987435105 cites W2063449571 @default.
• W1987435105 cites W2066362775 @default.
• W1987435105 cites W2087501975 @default.
• W1987435105 cites W2092414509 @default.
• W1987435105 cites W2097059816 @default.
• W1987435105 cites W2098498308 @default.
• W1987435105 cites W2100109186 @default.
• W1987435105 cites W2109312919 @default.
• W1987435105 cites W2110838395 @default.
• W1987435105 cites W2114369768 @default.
• W1987435105 cites W2114999652 @default.
• W1987435105 cites W2116335962 @default.
• W1987435105 cites W2117055771 @default.
• W1987435105 cites W2117147132 @default.
• W1987435105 cites W2122794276 @default.
• W1987435105 cites W2122872613 @default.
• W1987435105 cites W2137565061 @default.
• W1987435105 cites W2141885858 @default.
• W1987435105 cites W2148788789 @default.
• W1987435105 cites W2162703948 @default.
• W1987435105 cites W2168745915 @default.
• W1987435105 cites W2169522591 @default.
• W1987435105 cites W2174184943 @default.
• W1987435105 cites W2495229872 @default.
• W1987435105 cites W4210323379 @default.
• W1987435105 cites W4230982954 @default.
• W1987435105 cites W4243829678 @default.
• W1987435105 cites W4247371865 @default.
• W1987435105 doi "https://doi.org/10.1007/s10709-011-9560-6" @default.
• W1987435105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3980844" @default.
• W1987435105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21400220" @default.
• W1987435105 hasPublicationYear "2011" @default.
• W1987435105 type Work @default.
• W1987435105 sameAs 1987435105 @default.
• W1987435105 citedByCount "0" @default.
• W1987435105 crossrefType "journal-article" @default.
• W1987435105 hasAuthorship W1987435105A5031831796 @default.
• W1987435105 hasAuthorship W1987435105A5072779805 @default.
• W1987435105 hasBestOaLocation W19874351052 @default.
• W1987435105 hasConcept C104317684 @default.
• W1987435105 hasConcept C135763542 @default.
• W1987435105 hasConcept C141231307 @default.
• W1987435105 hasConcept C153209595 @default.
• W1987435105 hasConcept C154945302 @default.
• W1987435105 hasConcept C193252679 @default.
• W1987435105 hasConcept C35605836 @default.
• W1987435105 hasConcept C41008148 @default.
• W1987435105 hasConcept C51679486 @default.
• W1987435105 hasConcept C54355233 @default.
• W1987435105 hasConcept C70721500 @default.
• W1987435105 hasConcept C78458016 @default.
• W1987435105 hasConcept C79337645 @default.
• W1987435105 hasConcept C86803240 @default.
• W1987435105 hasConcept C90132467 @default.
• W1987435105 hasConceptScore W1987435105C104317684 @default.
• W1987435105 hasConceptScore W1987435105C135763542 @default.
• W1987435105 hasConceptScore W1987435105C141231307 @default.
• W1987435105 hasConceptScore W1987435105C153209595 @default.
• W1987435105 hasConceptScore W1987435105C154945302 @default.
• W1987435105 hasConceptScore W1987435105C193252679 @default.
• W1987435105 hasConceptScore W1987435105C35605836 @default.
• W1987435105 hasConceptScore W1987435105C41008148 @default.
• W1987435105 hasConceptScore W1987435105C51679486 @default.
• W1987435105 hasConceptScore W1987435105C54355233 @default.
• W1987435105 hasConceptScore W1987435105C70721500 @default.
• W1987435105 hasConceptScore W1987435105C78458016 @default.
• W1987435105 hasConceptScore W1987435105C79337645 @default.
• W1987435105 hasConceptScore W1987435105C86803240 @default.
• W1987435105 hasConceptScore W1987435105C90132467 @default.
• W1987435105 hasIssue "5" @default.
• W1987435105 hasLocation W19874351051 @default.
• W1987435105 hasLocation W19874351052 @default.
• W1987435105 hasLocation W19874351053 @default.

• next