FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987441618> ?p ?o ?g. }

• W1987441618 endingPage "1766" @default.
• W1987441618 startingPage "1758" @default.
• W1987441618 abstract "The KG-1a cell line is developed from a human stem cell myeloproliferative neoplasm as the result of intragenic disruption and a chromosomal translocation of the FGFR1 gene and the FGFR1OP2 gene encoding a protein of unknown function called FOP2 (FGFR1 Oncogene Partner 2). The resulting fusion protein FOP2-FGFR1 is soluble and has constitutive tyrosine kinase activity. Since the heat shock protein HSP90 and its co-chaperone CDC37 have been shown to stabilize many oncogenic proteins, we investigated the requirement for HSP90 or HSP90-CDC37 assistance to maintain the stability or activity of FOP2-FGFR1 expressed in KG-1a cells. We found that HSP90-CDC37 forms a permanent complex with FOP2-FGFR1. This results in protection against degradation of FOP2-FGFR1 and holds the oncoprotein in a permanently active conformation. Inhibition of HSP90 or depletion of CDC37 or heat shock factor 1 (HSF1) reduced the expression level of FOP2-FGFR1 and was sufficient to block the oncoprotein induced proliferation of KG-1a cells. We conclude that the driver of malignancy in KG-1a leukemic cells, FOP2-FGFR1, is an HSP90 addicted oncoprotein. This provides a rationale for the therapeutic use of HSP90 inhibitors in myeloid leukemias that contain FGFR fusion proteins." @default.
• W1987441618 created "2016-06-24" @default.
• W1987441618 creator A5033515024 @default.
• W1987441618 creator A5040387494 @default.
• W1987441618 creator A5045352516 @default.
• W1987441618 creator A5076166991 @default.
• W1987441618 date "2011-11-01" @default.
• W1987441618 modified "2023-10-03" @default.
• W1987441618 title "The driver of malignancy in KG-1a leukemic cells, FGFR1OP2–FGFR1, encodes an HSP90 addicted oncoprotein" @default.
• W1987441618 cites W114060563 @default.
• W1987441618 cites W11727989 @default.
• W1987441618 cites W1542698523 @default.
• W1987441618 cites W1968942815 @default.
• W1987441618 cites W1980033613 @default.
• W1987441618 cites W1982717121 @default.
• W1987441618 cites W1988476050 @default.
• W1987441618 cites W1988760251 @default.
• W1987441618 cites W1988963406 @default.
• W1987441618 cites W1991196199 @default.
• W1987441618 cites W1993549724 @default.
• W1987441618 cites W1994823455 @default.
• W1987441618 cites W2007466764 @default.
• W1987441618 cites W2011219963 @default.
• W1987441618 cites W2019431066 @default.
• W1987441618 cites W2022531767 @default.
• W1987441618 cites W2027239974 @default.
• W1987441618 cites W2027684265 @default.
• W1987441618 cites W2032224060 @default.
• W1987441618 cites W2052592894 @default.
• W1987441618 cites W2053356355 @default.
• W1987441618 cites W2053479303 @default.
• W1987441618 cites W2055304293 @default.
• W1987441618 cites W2055339736 @default.
• W1987441618 cites W2060902443 @default.
• W1987441618 cites W2063956958 @default.
• W1987441618 cites W2064534470 @default.
• W1987441618 cites W2066285199 @default.
• W1987441618 cites W2066844134 @default.
• W1987441618 cites W2076159058 @default.
• W1987441618 cites W2077813812 @default.
• W1987441618 cites W2079569030 @default.
• W1987441618 cites W2084795601 @default.
• W1987441618 cites W2096950509 @default.
• W1987441618 cites W2098224915 @default.
• W1987441618 cites W2100881236 @default.
• W1987441618 cites W2106835772 @default.
• W1987441618 cites W2112849051 @default.
• W1987441618 cites W2113038168 @default.
• W1987441618 cites W2115527176 @default.
• W1987441618 cites W2119976307 @default.
• W1987441618 cites W2120316538 @default.
• W1987441618 cites W2121431024 @default.
• W1987441618 cites W2124715023 @default.
• W1987441618 cites W2129004089 @default.
• W1987441618 cites W2129381779 @default.
• W1987441618 cites W2129566355 @default.
• W1987441618 cites W2140702339 @default.
• W1987441618 cites W2157360354 @default.
• W1987441618 cites W2161696113 @default.
• W1987441618 cites W2167889783 @default.
• W1987441618 cites W2410660303 @default.
• W1987441618 cites W2557828168 @default.
• W1987441618 cites W313262789 @default.
• W1987441618 doi "https://doi.org/10.1016/j.cellsig.2011.06.010" @default.
• W1987441618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21745565" @default.
• W1987441618 hasPublicationYear "2011" @default.
• W1987441618 type Work @default.
• W1987441618 sameAs 1987441618 @default.
• W1987441618 citedByCount "18" @default.
• W1987441618 countsByYear W19874416182012 @default.
• W1987441618 countsByYear W19874416182013 @default.
• W1987441618 countsByYear W19874416182015 @default.
• W1987441618 countsByYear W19874416182016 @default.
• W1987441618 countsByYear W19874416182017 @default.
• W1987441618 countsByYear W19874416182018 @default.
• W1987441618 countsByYear W19874416182019 @default.
• W1987441618 countsByYear W19874416182020 @default.
• W1987441618 countsByYear W19874416182021 @default.
• W1987441618 countsByYear W19874416182022 @default.
• W1987441618 crossrefType "journal-article" @default.
• W1987441618 hasAuthorship W1987441618A5033515024 @default.
• W1987441618 hasAuthorship W1987441618A5040387494 @default.
• W1987441618 hasAuthorship W1987441618A5045352516 @default.
• W1987441618 hasAuthorship W1987441618A5076166991 @default.
• W1987441618 hasConcept C104317684 @default.
• W1987441618 hasConcept C104615370 @default.
• W1987441618 hasConcept C123894998 @default.
• W1987441618 hasConcept C170493617 @default.
• W1987441618 hasConcept C205260736 @default.
• W1987441618 hasConcept C2775932338 @default.
• W1987441618 hasConcept C2777560012 @default.
• W1987441618 hasConcept C40767141 @default.
• W1987441618 hasConcept C49418065 @default.
• W1987441618 hasConcept C502942594 @default.
• W1987441618 hasConcept C55493867 @default.
• W1987441618 hasConcept C74373430 @default.
• W1987441618 hasConcept C86803240 @default.
• W1987441618 hasConcept C95444343 @default.

• next