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• W1987444000 endingPage "10" @default.
• W1987444000 startingPage "1" @default.
• W1987444000 abstract "Identifying and characterizing Leishmania donovani genes and the proteins they encode for their role in pathogenesis can reveal the value of this approach for finding new drug targets. Effective drug targets are likely to be proteins differentially expressed or required in the amastigote life cycle stage found in the patient. Several examples and their potential for chemotherapeutic disruption are presented. A pathway nearly ubiquitous in living cells targeted by anticancer drugs, the ubiquitin system, is examined. New findings in ubiquitin and ubiquitin-like modifiers in Leishmania show how disruption of those pathways could point to additional drug targets. The programmed cell death pathway, now recognized among protozoan parasites, is reviewed for some of its components and evidence that suggests they could be targeted for antiparasitic drug therapy. Finally, the endoplasmic reticulum quality control system is involved in secretion of many virulence factors. How disruptions in this pathway reduce virulence as evidence for potential drug targets is presented." @default.
• W1987444000 created "2016-06-24" @default.
• W1987444000 creator A5000479943 @default.
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• W1987444000 creator A5060893561 @default.
• W1987444000 creator A5072305151 @default.
• W1987444000 creator A5089647417 @default.
• W1987444000 date "2011-06-26" @default.
• W1987444000 modified "2023-10-13" @default.
• W1987444000 title "Identification and Characterization of Genes Involved in<i>Leishmania</i>Pathogenesis: The Potential for Drug Target Selection" @default.
• W1987444000 cites W1494714889 @default.
• W1987444000 cites W1518789549 @default.
• W1987444000 cites W1556490787 @default.
• W1987444000 cites W1657174325 @default.
• W1987444000 cites W1964308028 @default.
• W1987444000 cites W1967518441 @default.
• W1987444000 cites W1971170594 @default.
• W1987444000 cites W1974828967 @default.
• W1987444000 cites W1978717905 @default.
• W1987444000 cites W1978755000 @default.
• W1987444000 cites W1979080877 @default.
• W1987444000 cites W1985275612 @default.
• W1987444000 cites W1986386808 @default.
• W1987444000 cites W1988204795 @default.
• W1987444000 cites W1992503089 @default.
• W1987444000 cites W1995153010 @default.
• W1987444000 cites W1999597112 @default.
• W1987444000 cites W2001114326 @default.
• W1987444000 cites W2002033708 @default.
• W1987444000 cites W2004051711 @default.
• W1987444000 cites W2011060806 @default.
• W1987444000 cites W2011414653 @default.
• W1987444000 cites W2014185803 @default.
• W1987444000 cites W2014973634 @default.
• W1987444000 cites W2015140167 @default.
• W1987444000 cites W2016180501 @default.
• W1987444000 cites W2017089103 @default.
• W1987444000 cites W2018093809 @default.
• W1987444000 cites W2020031294 @default.
• W1987444000 cites W2025257662 @default.
• W1987444000 cites W2025277548 @default.
• W1987444000 cites W2026204832 @default.
• W1987444000 cites W2026339411 @default.
• W1987444000 cites W2028070445 @default.
• W1987444000 cites W2029357632 @default.
• W1987444000 cites W2031153554 @default.
• W1987444000 cites W2032739426 @default.
• W1987444000 cites W2034087450 @default.
• W1987444000 cites W2034995377 @default.
• W1987444000 cites W2036594992 @default.
• W1987444000 cites W2036607853 @default.
• W1987444000 cites W2036992538 @default.
• W1987444000 cites W2042175198 @default.
• W1987444000 cites W2042990622 @default.
• W1987444000 cites W2043088098 @default.
• W1987444000 cites W2043655466 @default.
• W1987444000 cites W2047042383 @default.
• W1987444000 cites W2057855489 @default.
• W1987444000 cites W2066954635 @default.
• W1987444000 cites W2075635047 @default.
• W1987444000 cites W2075915930 @default.
• W1987444000 cites W2077169276 @default.
• W1987444000 cites W2081639435 @default.
• W1987444000 cites W2082399236 @default.
• W1987444000 cites W2082656494 @default.
• W1987444000 cites W2091788742 @default.
• W1987444000 cites W2103517208 @default.
• W1987444000 cites W2104325550 @default.
• W1987444000 cites W2104365617 @default.
• W1987444000 cites W2105105987 @default.
• W1987444000 cites W2105259353 @default.
• W1987444000 cites W2106217467 @default.
• W1987444000 cites W2107468208 @default.
• W1987444000 cites W2109120434 @default.
• W1987444000 cites W2112560211 @default.
• W1987444000 cites W2118693452 @default.
• W1987444000 cites W2121297416 @default.
• W1987444000 cites W2125044300 @default.
• W1987444000 cites W2126472716 @default.
• W1987444000 cites W2126812590 @default.
• W1987444000 cites W2127505755 @default.
• W1987444000 cites W2138846998 @default.
• W1987444000 cites W2139206998 @default.
• W1987444000 cites W2139224410 @default.
• W1987444000 cites W2140151996 @default.
• W1987444000 cites W2141342336 @default.
• W1987444000 cites W2141360780 @default.
• W1987444000 cites W2150664393 @default.
• W1987444000 cites W2154316070 @default.
• W1987444000 cites W2157980713 @default.
• W1987444000 cites W2160888554 @default.
• W1987444000 cites W2166931588 @default.
• W1987444000 cites W2166987747 @default.
• W1987444000 cites W2168883367 @default.
• W1987444000 cites W2171043246 @default.
• W1987444000 cites W4248396965 @default.
• W1987444000 cites W4254612948 @default.

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