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- W1987444426 endingPage "226" @default.
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- W1987444426 abstract "There are many lines of evidence showing that oxidative stress and aberrant mitogenic changes have important roles in the pathogenesis of Alzheimer's disease (AD). However, although both oxidative stress and cell cycle-related abnormalities are early events, occurring before any cytopathology, the relation between these two events, and their role in pathophysiology was, until recently, unclear. However, on the basis of studies of mitogenic and oxidative stress signalling pathways in AD, we proposed a two-hit hypothesis which states that although either oxidative stress or abnormalities in mitotic signalling can independently serve as initiators, both processes are necessary to propagate disease pathogenesis. In this paper, we summarise evidence for oxidative stress and abnormal mitotic alterations in AD and explain the two-hit hypothesis by describing how both mechanisms are necessary and invariant features of disease." @default.
- W1987444426 created "2016-06-24" @default.
- W1987444426 creator A5018613159 @default.
- W1987444426 creator A5021420538 @default.
- W1987444426 creator A5071772212 @default.
- W1987444426 creator A5085648694 @default.
- W1987444426 date "2004-04-01" @default.
- W1987444426 modified "2023-10-14" @default.
- W1987444426 title "Alzheimer's disease: the two-hit hypothesis" @default.
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