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- W1987444800 abstract "Low (up to 100 nM) and high (≈100 μM) concentrations of lanthanides and Ca2+-ions, respectively, stimulated [3H]tyramine binding ([3H]TY) to rat striatal membranes, a putative marker for the vesicular transporter of dopamine. On the other hand, lanthanides (≈100 μM) inhibited or stimulated TY binding in striatal and extrastriatal (cortex, cerebellum) tissues, respectively. The binding increases by lanthanum (La3+) appeared to depend on endogenous Ca2+, whereas, those induced in EDTA-pre-treated membranes were Ca2+-independent. The La3+-induced, apparent increase in the Bmax for [3H]TY binding seemed to reflect a retarded rate of dissociation of the ligand from its targets, rather than a larger availability of functionally-relevant, vesicular transport-related TY sites. This indicates uncertain mechanisms of present La3+ effects." @default.
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- W1987444800 date "1999-02-01" @default.
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- W1987444800 title "Lanthanides stimulate [3H]tyramine binding in the rat striatum" @default.
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- W1987444800 doi "https://doi.org/10.1016/s0304-3940(98)01017-9" @default.
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