FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987445088> ?p ?o ?g. }

• W1987445088 endingPage "11" @default.
• W1987445088 startingPage "4" @default.
• W1987445088 abstract "We tested capabilities of drugs elevating extracellular adenosine and of granulocyte colony-stimulating factor (G-CSF) given alone or in combination to modulate regeneration from severe myelosuppression resulting from combined exposure of mice to ionizing radiation and carboplatin. Elevation of extracellular adenosine was induced by joint administration of dipyridamole (DP), a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), serving as an adenosine prodrug. DP+AMP, G-CSF or all these drugs in combination were administered in a 4-d treatment regimen starting on day 3 after induction of myelosuppression. Comparable enhancements of haematopoietic regeneration due to elevation of extracellular adenosine or to action of G-CSF were demonstrated as shown by elevated numbers of haematopoietic progenitor cells for granulocytes/macrophages (GM-CFC) and erythrocytes (BFU-E) in the bone marrow and spleen in early time intervals after termination of the drug treatment, i.e. on days 7 and 10 after induction of myelosuppression. Coadministration of all the drugs further potentiated the restoration of progenitor cell pools in the haematopoietic organs. The effects of the drug treatments on progenitor cells were reflected in the peripheral blood in later time intervals of days 15 and 20 after induction of myelosuppression, especially as significantly elevated numbers of granulocytes and less pronounced elevation of lymphocytes and erythrocytes. The results substantiate the potential of drugs elevating extracellular adenosine for clinical utilization in myelosuppressive states, e.g. those accompanying oncological radio- and chemotherapy." @default.
• W1987445088 created "2016-06-24" @default.
• W1987445088 creator A5000298488 @default.
• W1987445088 creator A5005670021 @default.
• W1987445088 creator A5010237677 @default.
• W1987445088 creator A5027994902 @default.
• W1987445088 creator A5029115574 @default.
• W1987445088 creator A5030398721 @default.
• W1987445088 creator A5088970834 @default.
• W1987445088 date "2002-01-01" @default.
• W1987445088 modified "2023-09-26" @default.
• W1987445088 title "Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myelosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor" @default.
• W1987445088 cites W1494118888 @default.
• W1987445088 cites W1924264643 @default.
• W1987445088 cites W1971954940 @default.
• W1987445088 cites W1976365732 @default.
• W1987445088 cites W1982482255 @default.
• W1987445088 cites W202042235 @default.
• W1987445088 cites W2037262370 @default.
• W1987445088 cites W2041947486 @default.
• W1987445088 cites W2046451463 @default.
• W1987445088 cites W2086850748 @default.
• W1987445088 cites W2087309427 @default.
• W1987445088 cites W2094319340 @default.
• W1987445088 cites W2129667982 @default.
• W1987445088 cites W2137835252 @default.
• W1987445088 cites W2153486543 @default.
• W1987445088 cites W2164666367 @default.
• W1987445088 cites W2168551681 @default.
• W1987445088 cites W2171680307 @default.
• W1987445088 cites W2330698242 @default.
• W1987445088 cites W2344615469 @default.
• W1987445088 cites W300558949 @default.
• W1987445088 cites W301040576 @default.
• W1987445088 cites W4242225414 @default.
• W1987445088 doi "https://doi.org/10.1034/j.1600-0609.2002.00564.x" @default.
• W1987445088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11995629" @default.
• W1987445088 hasPublicationYear "2002" @default.
• W1987445088 type Work @default.
• W1987445088 sameAs 1987445088 @default.
• W1987445088 citedByCount "27" @default.
• W1987445088 countsByYear W19874450882012 @default.
• W1987445088 countsByYear W19874450882013 @default.
• W1987445088 countsByYear W19874450882014 @default.
• W1987445088 countsByYear W19874450882022 @default.
• W1987445088 crossrefType "journal-article" @default.
• W1987445088 hasAuthorship W1987445088A5000298488 @default.
• W1987445088 hasAuthorship W1987445088A5005670021 @default.
• W1987445088 hasAuthorship W1987445088A5010237677 @default.
• W1987445088 hasAuthorship W1987445088A5027994902 @default.
• W1987445088 hasAuthorship W1987445088A5029115574 @default.
• W1987445088 hasAuthorship W1987445088A5030398721 @default.
• W1987445088 hasAuthorship W1987445088A5088970834 @default.
• W1987445088 hasConcept C109159458 @default.
• W1987445088 hasConcept C126322002 @default.
• W1987445088 hasConcept C201750760 @default.
• W1987445088 hasConcept C203014093 @default.
• W1987445088 hasConcept C2776694085 @default.
• W1987445088 hasConcept C2776991684 @default.
• W1987445088 hasConcept C2777767877 @default.
• W1987445088 hasConcept C2777983669 @default.
• W1987445088 hasConcept C2780007613 @default.
• W1987445088 hasConcept C28328180 @default.
• W1987445088 hasConcept C28406088 @default.
• W1987445088 hasConcept C71924100 @default.
• W1987445088 hasConcept C86803240 @default.
• W1987445088 hasConcept C95444343 @default.
• W1987445088 hasConcept C98274493 @default.
• W1987445088 hasConceptScore W1987445088C109159458 @default.
• W1987445088 hasConceptScore W1987445088C126322002 @default.
• W1987445088 hasConceptScore W1987445088C201750760 @default.
• W1987445088 hasConceptScore W1987445088C203014093 @default.
• W1987445088 hasConceptScore W1987445088C2776694085 @default.
• W1987445088 hasConceptScore W1987445088C2776991684 @default.
• W1987445088 hasConceptScore W1987445088C2777767877 @default.
• W1987445088 hasConceptScore W1987445088C2777983669 @default.
• W1987445088 hasConceptScore W1987445088C2780007613 @default.
• W1987445088 hasConceptScore W1987445088C28328180 @default.
• W1987445088 hasConceptScore W1987445088C28406088 @default.
• W1987445088 hasConceptScore W1987445088C71924100 @default.
• W1987445088 hasConceptScore W1987445088C86803240 @default.
• W1987445088 hasConceptScore W1987445088C95444343 @default.
• W1987445088 hasConceptScore W1987445088C98274493 @default.
• W1987445088 hasIssue "1" @default.
• W1987445088 hasLocation W19874450881 @default.
• W1987445088 hasLocation W19874450882 @default.
• W1987445088 hasOpenAccess W1987445088 @default.
• W1987445088 hasPrimaryLocation W19874450881 @default.
• W1987445088 hasRelatedWork W1567835511 @default.
• W1987445088 hasRelatedWork W2024284055 @default.
• W1987445088 hasRelatedWork W2036046147 @default.
• W1987445088 hasRelatedWork W2077902477 @default.
• W1987445088 hasRelatedWork W2082990692 @default.
• W1987445088 hasRelatedWork W2285393345 @default.
• W1987445088 hasRelatedWork W2301552594 @default.
• W1987445088 hasRelatedWork W2339749170 @default.
• W1987445088 hasRelatedWork W4236581201 @default.
• W1987445088 hasRelatedWork W2272442949 @default.

• next