FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987449626> ?p ?o ?g. }

• W1987449626 endingPage "6022" @default.
• W1987449626 startingPage "6015" @default.
• W1987449626 abstract "The most common chromosomal translocation in liposarcomas, t(12;16)(q13;p11), creates the FUS/TLS-CHOP fusion gene. We previously developed a mouse model of liposarcoma by expressing FUS-CHOP in murine mesenchymal stem cells. In order to understand how FUS-CHOP can initiate liposarcoma, we have now generated transgenic mice expressing altered forms of the FUS-CHOP protein. Transgenic mice expressing high levels of CHOP, which lacks the FUS domain, do not develop any tumor despite its tumorigenicity in vitro and widespread activity of the EF1alpha promoter. These animals consistently show the accumulation of a glycoprotein material within the terminally differentiated adipocytes, a characteristic figure of liposarcomas associated with FUS-CHOP. On the contrary, transgenic mice expressing the altered form of FUS-CHOP created by the in frame fusion of the FUS domain to the carboxy end of CHOP (CHOP-FUS) developed liposarcomas. No tumors of other tissues were found in these transgenic mice despite widespread activity of the EF1alpha promoter. The characteristics of the liposarcomas arising in the CHOP-FUS mice were very similar to those previously observed in our FUS-CHOP transgenic mice indicating that the FUS domain is required not only for transformation but also influences the phenotype of the tumor cells. These results provide evidence that the FUS domain of FUS-CHOP plays a specific and critical role in the pathogenesis of liposarcoma." @default.
• W1987449626 created "2016-06-24" @default.
• W1987449626 creator A5016255484 @default.
• W1987449626 creator A5020633628 @default.
• W1987449626 creator A5053894540 @default.
• W1987449626 creator A5063205640 @default.
• W1987449626 creator A5073028672 @default.
• W1987449626 creator A5075974674 @default.
• W1987449626 creator A5080912506 @default.
• W1987449626 creator A5088545099 @default.
• W1987449626 date "2000-12-07" @default.
• W1987449626 modified "2023-10-17" @default.
• W1987449626 title "Liposarcoma initiated by FUS/TLS-CHOP: the FUS/TLS domain plays a critical role in the pathogenesis of liposarcoma" @default.
• W1987449626 cites W1545128241 @default.
• W1987449626 cites W1831056283 @default.
• W1987449626 cites W1861749169 @default.
• W1987449626 cites W1964377967 @default.
• W1987449626 cites W1975160900 @default.
• W1987449626 cites W1977694859 @default.
• W1987449626 cites W1987152513 @default.
• W1987449626 cites W1990114475 @default.
• W1987449626 cites W1992063032 @default.
• W1987449626 cites W2032270986 @default.
• W1987449626 cites W2033994846 @default.
• W1987449626 cites W2037502768 @default.
• W1987449626 cites W2045978770 @default.
• W1987449626 cites W2052814385 @default.
• W1987449626 cites W2059477771 @default.
• W1987449626 cites W2059707627 @default.
• W1987449626 cites W2075185862 @default.
• W1987449626 cites W2107755271 @default.
• W1987449626 cites W2133771702 @default.
• W1987449626 cites W2164322102 @default.
• W1987449626 cites W2168415166 @default.
• W1987449626 cites W4252570357 @default.
• W1987449626 doi "https://doi.org/10.1038/sj.onc.1204018" @default.
• W1987449626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11146553" @default.
• W1987449626 hasPublicationYear "2000" @default.
• W1987449626 type Work @default.
• W1987449626 sameAs 1987449626 @default.
• W1987449626 citedByCount "85" @default.
• W1987449626 countsByYear W19874496262012 @default.
• W1987449626 countsByYear W19874496262013 @default.
• W1987449626 countsByYear W19874496262014 @default.
• W1987449626 countsByYear W19874496262015 @default.
• W1987449626 countsByYear W19874496262016 @default.
• W1987449626 countsByYear W19874496262017 @default.
• W1987449626 countsByYear W19874496262018 @default.
• W1987449626 countsByYear W19874496262019 @default.
• W1987449626 countsByYear W19874496262020 @default.
• W1987449626 countsByYear W19874496262021 @default.
• W1987449626 countsByYear W19874496262022 @default.
• W1987449626 countsByYear W19874496262023 @default.
• W1987449626 crossrefType "journal-article" @default.
• W1987449626 hasAuthorship W1987449626A5016255484 @default.
• W1987449626 hasAuthorship W1987449626A5020633628 @default.
• W1987449626 hasAuthorship W1987449626A5053894540 @default.
• W1987449626 hasAuthorship W1987449626A5063205640 @default.
• W1987449626 hasAuthorship W1987449626A5073028672 @default.
• W1987449626 hasAuthorship W1987449626A5075974674 @default.
• W1987449626 hasAuthorship W1987449626A5080912506 @default.
• W1987449626 hasAuthorship W1987449626A5088545099 @default.
• W1987449626 hasBestOaLocation W19874496261 @default.
• W1987449626 hasConcept C102230213 @default.
• W1987449626 hasConcept C104317684 @default.
• W1987449626 hasConcept C141035611 @default.
• W1987449626 hasConcept C142724271 @default.
• W1987449626 hasConcept C158617107 @default.
• W1987449626 hasConcept C2778256501 @default.
• W1987449626 hasConcept C2779568860 @default.
• W1987449626 hasConcept C2779725641 @default.
• W1987449626 hasConcept C2781225692 @default.
• W1987449626 hasConcept C502942594 @default.
• W1987449626 hasConcept C54355233 @default.
• W1987449626 hasConcept C71924100 @default.
• W1987449626 hasConcept C86803240 @default.
• W1987449626 hasConcept C95444343 @default.
• W1987449626 hasConceptScore W1987449626C102230213 @default.
• W1987449626 hasConceptScore W1987449626C104317684 @default.
• W1987449626 hasConceptScore W1987449626C141035611 @default.
• W1987449626 hasConceptScore W1987449626C142724271 @default.
• W1987449626 hasConceptScore W1987449626C158617107 @default.
• W1987449626 hasConceptScore W1987449626C2778256501 @default.
• W1987449626 hasConceptScore W1987449626C2779568860 @default.
• W1987449626 hasConceptScore W1987449626C2779725641 @default.
• W1987449626 hasConceptScore W1987449626C2781225692 @default.
• W1987449626 hasConceptScore W1987449626C502942594 @default.
• W1987449626 hasConceptScore W1987449626C54355233 @default.
• W1987449626 hasConceptScore W1987449626C71924100 @default.
• W1987449626 hasConceptScore W1987449626C86803240 @default.
• W1987449626 hasConceptScore W1987449626C95444343 @default.
• W1987449626 hasIssue "52" @default.
• W1987449626 hasLocation W19874496261 @default.
• W1987449626 hasLocation W19874496262 @default.
• W1987449626 hasOpenAccess W1987449626 @default.
• W1987449626 hasPrimaryLocation W19874496261 @default.
• W1987449626 hasRelatedWork W2001208945 @default.
• W1987449626 hasRelatedWork W2045496998 @default.

• next