FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987452803> ?p ?o ?g. }

• W1987452803 endingPage "215" @default.
• W1987452803 startingPage "207" @default.
• W1987452803 abstract "The eukaryotic translation initiation factor eIF4E is a potent oncogene that promotes the nuclear export and translation of specific transcripts. Here, we have discovered that eIF4E alters the cytoplasmic face of the nuclear pore complex (NPC), which leads to enhanced mRNA export of eIF4E target mRNAs. Specifically, eIF4E substantially reduces the major component of the cytoplasmic fibrils of the NPC, RanBP2, relocalizes an associated nucleoporin, Nup214, and elevates RanBP1 and the RNA export factors, Gle1 and DDX19. Genetic or pharmacological inhibition of eIF4E impedes these effects. RanBP2 overexpression specifically inhibits the eIF4E mRNA export pathway and impairs oncogenic transformation by eIF4E. The RanBP2 cytoplasmic fibrils most likely slow the release and/or recycling of critical export factors to the nucleus. eIF4E overcomes this inhibitory mechanism by indirectly reducing levels of RanBP2. More generally, these results suggest that reprogramming the NPC is a means by which oncogenes can harness the proliferative capacity of the cell." @default.
• W1987452803 created "2016-06-24" @default.
• W1987452803 creator A5038806492 @default.
• W1987452803 creator A5076557834 @default.
• W1987452803 creator A5081655874 @default.
• W1987452803 creator A5089167705 @default.
• W1987452803 creator A5091624718 @default.
• W1987452803 date "2012-08-01" @default.
• W1987452803 modified "2023-09-29" @default.
• W1987452803 title "The Oncogene eIF4E Reprograms the Nuclear Pore Complex to Promote mRNA Export and Oncogenic Transformation" @default.
• W1987452803 cites W1486484928 @default.
• W1987452803 cites W1964996586 @default.
• W1987452803 cites W1966275499 @default.
• W1987452803 cites W1966448816 @default.
• W1987452803 cites W1968622004 @default.
• W1987452803 cites W1985285007 @default.
• W1987452803 cites W1986089358 @default.
• W1987452803 cites W1989112243 @default.
• W1987452803 cites W1993287040 @default.
• W1987452803 cites W1995146769 @default.
• W1987452803 cites W1996776924 @default.
• W1987452803 cites W1997806157 @default.
• W1987452803 cites W1998249270 @default.
• W1987452803 cites W2006150047 @default.
• W1987452803 cites W2006971960 @default.
• W1987452803 cites W2012538868 @default.
• W1987452803 cites W2020167518 @default.
• W1987452803 cites W2026512609 @default.
• W1987452803 cites W2026635576 @default.
• W1987452803 cites W2033171415 @default.
• W1987452803 cites W2033489247 @default.
• W1987452803 cites W2036947100 @default.
• W1987452803 cites W2045360857 @default.
• W1987452803 cites W2047766237 @default.
• W1987452803 cites W2056755041 @default.
• W1987452803 cites W2068410472 @default.
• W1987452803 cites W2069641384 @default.
• W1987452803 cites W2070615094 @default.
• W1987452803 cites W2083964225 @default.
• W1987452803 cites W2085664732 @default.
• W1987452803 cites W2091311543 @default.
• W1987452803 cites W2093408431 @default.
• W1987452803 cites W2112519486 @default.
• W1987452803 cites W2114154858 @default.
• W1987452803 cites W2114921531 @default.
• W1987452803 cites W2127417296 @default.
• W1987452803 cites W2132665334 @default.
• W1987452803 cites W2153894357 @default.
• W1987452803 cites W2155632240 @default.
• W1987452803 cites W2171167766 @default.
• W1987452803 doi "https://doi.org/10.1016/j.celrep.2012.07.007" @default.
• W1987452803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3463940" @default.
• W1987452803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22902403" @default.
• W1987452803 hasPublicationYear "2012" @default.
• W1987452803 type Work @default.
• W1987452803 sameAs 1987452803 @default.
• W1987452803 citedByCount "112" @default.
• W1987452803 countsByYear W19874528032013 @default.
• W1987452803 countsByYear W19874528032014 @default.
• W1987452803 countsByYear W19874528032015 @default.
• W1987452803 countsByYear W19874528032016 @default.
• W1987452803 countsByYear W19874528032017 @default.
• W1987452803 countsByYear W19874528032018 @default.
• W1987452803 countsByYear W19874528032019 @default.
• W1987452803 countsByYear W19874528032020 @default.
• W1987452803 countsByYear W19874528032021 @default.
• W1987452803 countsByYear W19874528032022 @default.
• W1987452803 countsByYear W19874528032023 @default.
• W1987452803 crossrefType "journal-article" @default.
• W1987452803 hasAuthorship W1987452803A5038806492 @default.
• W1987452803 hasAuthorship W1987452803A5076557834 @default.
• W1987452803 hasAuthorship W1987452803A5081655874 @default.
• W1987452803 hasAuthorship W1987452803A5089167705 @default.
• W1987452803 hasAuthorship W1987452803A5091624718 @default.
• W1987452803 hasBestOaLocation W19874528031 @default.
• W1987452803 hasConcept C104317684 @default.
• W1987452803 hasConcept C105580179 @default.
• W1987452803 hasConcept C126725582 @default.
• W1987452803 hasConcept C149364088 @default.
• W1987452803 hasConcept C161295673 @default.
• W1987452803 hasConcept C190062978 @default.
• W1987452803 hasConcept C2780114586 @default.
• W1987452803 hasConcept C2781018059 @default.
• W1987452803 hasConcept C29537977 @default.
• W1987452803 hasConcept C4718897 @default.
• W1987452803 hasConcept C54355233 @default.
• W1987452803 hasConcept C54757728 @default.
• W1987452803 hasConcept C59157529 @default.
• W1987452803 hasConcept C67705224 @default.
• W1987452803 hasConcept C68556195 @default.
• W1987452803 hasConcept C86803240 @default.
• W1987452803 hasConcept C95444343 @default.
• W1987452803 hasConceptScore W1987452803C104317684 @default.
• W1987452803 hasConceptScore W1987452803C105580179 @default.
• W1987452803 hasConceptScore W1987452803C126725582 @default.
• W1987452803 hasConceptScore W1987452803C149364088 @default.
• W1987452803 hasConceptScore W1987452803C161295673 @default.
• W1987452803 hasConceptScore W1987452803C190062978 @default.

• next