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• W1987454047 abstract "It is well known that the majority of geriatric patients with depression and mixed dementia have cardiovascular co-morbidities, which have an additional negative impact on cognition. There are no studies hitherto which have investigated the long-term effect of combined treatment (medications and non-pharmacological interventions) in this group of patients. This investigation is a part of an ongoing naturalistic study to explore the possibility of preventing cognitive decline in demented, depressed seniors by implementing a multifaceted treatment model. Here we present the data related to efficacy of 36 months of treatment of demented, depressed geriatric patients with cardiovascular co-morbidities. The study group consists of 38 patients (17 male, 21 female) with an average age of 72.34, who are diagnosed with mild dementia and depression and have a history of hypertension, CAD and dyslipidemia. Additionally, 18 (47.38%) have diabetes mellitus and 8 (21%) have prior strokes and head trauma. These patients were evaluated at baseline and in one, two, and three years of treatment. The medications included antidepressants (sertraline, citalopram, or venlafaxine XR, alone or in combination with bupropion XR) and cholinesterase inhibitors (donepezil, rivastigmine or galantamine alone or in combination with memantine) along with their regular medications. Non-pharmacological interventions included vitamins and supplements (multivitamins, vitamin E, Deplin, Alpha-Lipoic Acid, Acetyl-L-Carnitine, Omega-3 and Coenzyme Q-10), diet changes, and our recently developed brain activation program (a home-based protocol involving mild physical exercises and cognitive training). The assessment battery consists of 6 tests that evaluate attention, memory, and executive functions. The maximum significant cognitive improvement is seen at the end of 24 months of the treatment in MMSE, attention, memory, naming, construction, clock drawing, verbal fluency, and Ruff Frontal Fluency tests. At the end of 36 months of the treatment significant improvement is observed on attention, construction, and clock drawing. The rest of the tests show no signs of mental decline below base line for the entire period of the treatment. Our integrative treatment model in depressed, demented, elderly patients with cardiovascular co-morbidities was effective in delaying cognitive decline for 36 months." @default.
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• W1987454047 date "2009-07-01" @default.
• W1987454047 modified "2023-09-27" @default.
• W1987454047 title "P2-204: Preservation of cognitive functioning in depressed, demented geriatric patients with cardiovascular risk factors: An ongoing 3-year naturalistic study" @default.
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• W1987454047 doi "https://doi.org/10.1016/j.jalz.2009.04.517" @default.
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