FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987457462> ?p ?o ?g. }

• W1987457462 endingPage "26" @default.
• W1987457462 startingPage "20" @default.
• W1987457462 abstract "The expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in heart allografts is an important mechanism in response to ischemia/reperfusion (I/R) injury which represents the single major non-immunologic factor implicated in pathogenesis of chronic graft dysfunction (CGD). Adenoviral mediated overexpression of HIF-1alpha is a useful way to investigate the molecular mechanisms of I/R injury and the cardiac function during heart transplantation. The oxygen-dependent degradation (ODD) domain of HIF-1alpha can lead to degradation of the HIF-1alpha protein in normoxia. This will be an obstacle to steady expression of HIF-1alpha in heart allograft after transduction. In this study, we obtained the coding sequence of HIF-1alpha without ODD domain (HIF-1alphaDeltaODD) through a PCR-based method, and then generated the HIF-1alphaDeltaODD-expressing adenovirus. In normoxia, adenoviral mediated expression of HIF-1alphaDeltaODD shows constitutive activity in human cardiomyocytes, and can up-regulate heme oxygenase (HO)-1 mRNA levels significantly compared with the group transduced with HIF-1alpha-expressing adenovirus. The constructed HIF-1alphaDeltaODD-expressing adenovirus can be used to transduce allografts in animal studies to investigate the mechanism of CGD and provide a useful model to study the regulation mechanisms of genes regulated by HIF-1alpha alone." @default.
• W1987457462 created "2016-06-24" @default.
• W1987457462 creator A5020469612 @default.
• W1987457462 creator A5042945387 @default.
• W1987457462 creator A5062031783 @default.
• W1987457462 creator A5073529998 @default.
• W1987457462 creator A5074158503 @default.
• W1987457462 creator A5085736815 @default.
• W1987457462 date "2010-01-01" @default.
• W1987457462 modified "2023-09-26" @default.
• W1987457462 title "Construction of recombinant adenovirus vector containing a modified gene that codes for human hypoxia-inducible factor-1α without oxygen-dependent degradation domain" @default.
• W1987457462 cites W1749022239 @default.
• W1987457462 cites W1970074234 @default.
• W1987457462 cites W1973720695 @default.
• W1987457462 cites W1973957725 @default.
• W1987457462 cites W1983652707 @default.
• W1987457462 cites W1998078414 @default.
• W1987457462 cites W2009916250 @default.
• W1987457462 cites W2019684500 @default.
• W1987457462 cites W2058021996 @default.
• W1987457462 cites W2063960864 @default.
• W1987457462 cites W2069335522 @default.
• W1987457462 cites W2075054245 @default.
• W1987457462 cites W2085609942 @default.
• W1987457462 cites W2091856585 @default.
• W1987457462 cites W2113620806 @default.
• W1987457462 cites W2126440077 @default.
• W1987457462 cites W2134360290 @default.
• W1987457462 cites W2135371418 @default.
• W1987457462 cites W2135836641 @default.
• W1987457462 cites W2144625075 @default.
• W1987457462 cites W2171654757 @default.
• W1987457462 cites W2171750543 @default.
• W1987457462 cites W4250399467 @default.
• W1987457462 doi "https://doi.org/10.1016/j.plasmid.2009.09.002" @default.
• W1987457462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19766670" @default.
• W1987457462 hasPublicationYear "2010" @default.
• W1987457462 type Work @default.
• W1987457462 sameAs 1987457462 @default.
• W1987457462 citedByCount "9" @default.
• W1987457462 countsByYear W19874574622014 @default.
• W1987457462 countsByYear W19874574622015 @default.
• W1987457462 countsByYear W19874574622016 @default.
• W1987457462 countsByYear W19874574622020 @default.
• W1987457462 crossrefType "journal-article" @default.
• W1987457462 hasAuthorship W1987457462A5020469612 @default.
• W1987457462 hasAuthorship W1987457462A5042945387 @default.
• W1987457462 hasAuthorship W1987457462A5062031783 @default.
• W1987457462 hasAuthorship W1987457462A5073529998 @default.
• W1987457462 hasAuthorship W1987457462A5074158503 @default.
• W1987457462 hasAuthorship W1987457462A5085736815 @default.
• W1987457462 hasConcept C104317684 @default.
• W1987457462 hasConcept C111599444 @default.
• W1987457462 hasConcept C126322002 @default.
• W1987457462 hasConcept C153911025 @default.
• W1987457462 hasConcept C160450060 @default.
• W1987457462 hasConcept C181199279 @default.
• W1987457462 hasConcept C203014093 @default.
• W1987457462 hasConcept C2522874641 @default.
• W1987457462 hasConcept C2776217839 @default.
• W1987457462 hasConcept C2776954459 @default.
• W1987457462 hasConcept C2781036101 @default.
• W1987457462 hasConcept C2911091166 @default.
• W1987457462 hasConcept C32470452 @default.
• W1987457462 hasConcept C40767141 @default.
• W1987457462 hasConcept C55493867 @default.
• W1987457462 hasConcept C71924100 @default.
• W1987457462 hasConcept C86803240 @default.
• W1987457462 hasConcept C95444343 @default.
• W1987457462 hasConceptScore W1987457462C104317684 @default.
• W1987457462 hasConceptScore W1987457462C111599444 @default.
• W1987457462 hasConceptScore W1987457462C126322002 @default.
• W1987457462 hasConceptScore W1987457462C153911025 @default.
• W1987457462 hasConceptScore W1987457462C160450060 @default.
• W1987457462 hasConceptScore W1987457462C181199279 @default.
• W1987457462 hasConceptScore W1987457462C203014093 @default.
• W1987457462 hasConceptScore W1987457462C2522874641 @default.
• W1987457462 hasConceptScore W1987457462C2776217839 @default.
• W1987457462 hasConceptScore W1987457462C2776954459 @default.
• W1987457462 hasConceptScore W1987457462C2781036101 @default.
• W1987457462 hasConceptScore W1987457462C2911091166 @default.
• W1987457462 hasConceptScore W1987457462C32470452 @default.
• W1987457462 hasConceptScore W1987457462C40767141 @default.
• W1987457462 hasConceptScore W1987457462C55493867 @default.
• W1987457462 hasConceptScore W1987457462C71924100 @default.
• W1987457462 hasConceptScore W1987457462C86803240 @default.
• W1987457462 hasConceptScore W1987457462C95444343 @default.
• W1987457462 hasIssue "1" @default.
• W1987457462 hasLocation W19874574621 @default.
• W1987457462 hasLocation W19874574622 @default.
• W1987457462 hasOpenAccess W1987457462 @default.
• W1987457462 hasPrimaryLocation W19874574621 @default.
• W1987457462 hasRelatedWork W2332453328 @default.
• W1987457462 hasRelatedWork W2356563149 @default.
• W1987457462 hasRelatedWork W2358573645 @default.
• W1987457462 hasRelatedWork W2362192803 @default.
• W1987457462 hasRelatedWork W2365773158 @default.
• W1987457462 hasRelatedWork W2374247764 @default.

• next