Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987471885> ?p ?o ?g. }
- W1987471885 endingPage "1259" @default.
- W1987471885 startingPage "1255" @default.
- W1987471885 abstract "Glutamate neurotoxicity in cochlear hair cells was investigated by administering the glutamate agonist α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) into the scala tympani of Mongolian gerbils. AMPA administration caused the formation of large number of vacuoles in the inner hair cells (IHCs) and dendritic terminals. The number of degenerated hair cells was counted using rhodamine–phalloidin and Hoechst 33342 staining. The administration of 50 μM AMPA caused reversible elevation of the auditory brainstem response threshold without loss of IHCs. In contrast, 200 μM AMPA induced a substantial elevation of the auditory brainstem response threshold with the characteristic disappearance of IHCs. As cochlear ischemia involves excessive glutamate release, these results suggest that an elevated glutamate level in the cochlea is responsible for the progressive IHC death related to ischemic injury." @default.
- W1987471885 created "2016-06-24" @default.
- W1987471885 creator A5001488378 @default.
- W1987471885 creator A5011716729 @default.
- W1987471885 creator A5038773757 @default.
- W1987471885 creator A5040276430 @default.
- W1987471885 creator A5058467250 @default.
- W1987471885 creator A5066315558 @default.
- W1987471885 creator A5075430556 @default.
- W1987471885 date "2009-09-23" @default.
- W1987471885 modified "2023-10-12" @default.
- W1987471885 title "Glutamate agonist causes irreversible degeneration of inner hair cells" @default.
- W1987471885 cites W133907179 @default.
- W1987471885 cites W1809136836 @default.
- W1987471885 cites W1965122182 @default.
- W1987471885 cites W1967381132 @default.
- W1987471885 cites W1978268496 @default.
- W1987471885 cites W1995837200 @default.
- W1987471885 cites W1998994882 @default.
- W1987471885 cites W2004236531 @default.
- W1987471885 cites W2035750459 @default.
- W1987471885 cites W2042550512 @default.
- W1987471885 cites W2053573128 @default.
- W1987471885 cites W2068857579 @default.
- W1987471885 cites W2077629409 @default.
- W1987471885 cites W2085563011 @default.
- W1987471885 cites W2085571273 @default.
- W1987471885 cites W2090772730 @default.
- W1987471885 cites W2115680008 @default.
- W1987471885 cites W2160483038 @default.
- W1987471885 doi "https://doi.org/10.1097/wnr.0b013e32833017ce" @default.
- W1987471885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19625985" @default.
- W1987471885 hasPublicationYear "2009" @default.
- W1987471885 type Work @default.
- W1987471885 sameAs 1987471885 @default.
- W1987471885 citedByCount "13" @default.
- W1987471885 countsByYear W19874718852013 @default.
- W1987471885 countsByYear W19874718852015 @default.
- W1987471885 countsByYear W19874718852017 @default.
- W1987471885 countsByYear W19874718852018 @default.
- W1987471885 countsByYear W19874718852019 @default.
- W1987471885 countsByYear W19874718852021 @default.
- W1987471885 countsByYear W19874718852023 @default.
- W1987471885 crossrefType "journal-article" @default.
- W1987471885 hasAuthorship W1987471885A5001488378 @default.
- W1987471885 hasAuthorship W1987471885A5011716729 @default.
- W1987471885 hasAuthorship W1987471885A5038773757 @default.
- W1987471885 hasAuthorship W1987471885A5040276430 @default.
- W1987471885 hasAuthorship W1987471885A5058467250 @default.
- W1987471885 hasAuthorship W1987471885A5066315558 @default.
- W1987471885 hasAuthorship W1987471885A5075430556 @default.
- W1987471885 hasConcept C105702510 @default.
- W1987471885 hasConcept C126322002 @default.
- W1987471885 hasConcept C160268369 @default.
- W1987471885 hasConcept C169760540 @default.
- W1987471885 hasConcept C170493617 @default.
- W1987471885 hasConcept C185592680 @default.
- W1987471885 hasConcept C2778938600 @default.
- W1987471885 hasConcept C2780130748 @default.
- W1987471885 hasConcept C2780222073 @default.
- W1987471885 hasConcept C541997718 @default.
- W1987471885 hasConcept C551621295 @default.
- W1987471885 hasConcept C61174792 @default.
- W1987471885 hasConcept C71924100 @default.
- W1987471885 hasConcept C86803240 @default.
- W1987471885 hasConceptScore W1987471885C105702510 @default.
- W1987471885 hasConceptScore W1987471885C126322002 @default.
- W1987471885 hasConceptScore W1987471885C160268369 @default.
- W1987471885 hasConceptScore W1987471885C169760540 @default.
- W1987471885 hasConceptScore W1987471885C170493617 @default.
- W1987471885 hasConceptScore W1987471885C185592680 @default.
- W1987471885 hasConceptScore W1987471885C2778938600 @default.
- W1987471885 hasConceptScore W1987471885C2780130748 @default.
- W1987471885 hasConceptScore W1987471885C2780222073 @default.
- W1987471885 hasConceptScore W1987471885C541997718 @default.
- W1987471885 hasConceptScore W1987471885C551621295 @default.
- W1987471885 hasConceptScore W1987471885C61174792 @default.
- W1987471885 hasConceptScore W1987471885C71924100 @default.
- W1987471885 hasConceptScore W1987471885C86803240 @default.
- W1987471885 hasIssue "14" @default.
- W1987471885 hasLocation W19874718851 @default.
- W1987471885 hasLocation W19874718852 @default.
- W1987471885 hasOpenAccess W1987471885 @default.
- W1987471885 hasPrimaryLocation W19874718851 @default.
- W1987471885 hasRelatedWork W1554664283 @default.
- W1987471885 hasRelatedWork W1977771311 @default.
- W1987471885 hasRelatedWork W1993625524 @default.
- W1987471885 hasRelatedWork W2001826608 @default.
- W1987471885 hasRelatedWork W2016100534 @default.
- W1987471885 hasRelatedWork W2038909506 @default.
- W1987471885 hasRelatedWork W2064586431 @default.
- W1987471885 hasRelatedWork W2067642731 @default.
- W1987471885 hasRelatedWork W2280007336 @default.
- W1987471885 hasRelatedWork W3201075100 @default.
- W1987471885 hasVolume "20" @default.
- W1987471885 isParatext "false" @default.
- W1987471885 isRetracted "false" @default.
- W1987471885 magId "1987471885" @default.