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• W1987486596 endingPage "1852" @default.
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• W1987486596 abstract "We report on a subset of cells that co-purify with CD45-positive/Lineage minus (CD45pos/Linminus) hematopoietic cells that are capable of in vitro differentiation into multi-potential cells including cells with neuroectoderm properties. Although these cells are CD45 positive and have properties similar to CD45-negative mesenchymal progenitor cells (MPC) derived from bone marrow (BM), they are neither hematopoietic cells nor mesenchymal cells. These CD45pos/Linminus cells can be expanded in vitro, express the stem cell genes Oct-4 and Nanog and can be induced to differentiate into endothelial cells, osteoblasts, muscle cells and neural cells at frequencies similar to those reported for bone marrow mesenchymal cells. Long-term culture of these cells followed by transplantation into NOD/SCID mice resulted in positive bone marrow stromal cell engraftment but not hematopoietic engraftment, suggesting that despite their CD45-positive status these cells do not have the same properties as hematopoietic stem cells. Clonal cell analysis determined that the culture period caused a broadening in the differentiation potential of the starting population." @default.
• W1987486596 created "2016-06-24" @default.
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• W1987486596 date "2007-05-01" @default.
• W1987486596 modified "2023-09-24" @default.
• W1987486596 title "Identification and analysis of in vitro cultured CD45-positive cells capable of multi-lineage differentiation" @default.
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• W1987486596 doi "https://doi.org/10.1016/j.yexcr.2007.02.029" @default.
• W1987486596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17433293" @default.
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