Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987488246> ?p ?o ?g. }
- W1987488246 endingPage "894" @default.
- W1987488246 startingPage "889" @default.
- W1987488246 abstract "Endothelial function is impaired in essential hypertension. T-type but not L-type voltage-gated Ca2+ channels were detected in the vascular endothelium. The purpose of the present study was to clarify the role of T-type Ca2+ channels in endothelial function. We studied flow-mediated vasodilation (FMD) and sublingual nitroglycerin (NTG)-induced vasodilation in the brachial artery. Forty patients with essential hypertension were randomly assigned to treatment with efonidipine, a T- and L-type Ca2+ channel blocker, or with nifedipine, an L-type Ca2+ channel blocker. Twenty healthy normotensive individuals were included as a control group. In patients with essential hypertension, FMD was attenuated and NTG was similar that of compared to healthy controls. After 12 weeks, the decrease in mean blood pressure in the efonidipine and nifedipine groups were similar. The endothelial function index, a ratio of FMD/NTG, was significantly increased by efonidipine (73±24 to 94±20%) but unchanged by nifedipine. Urinary excretion 8-hydroxy-2′-deoxyguanosine (8-OHdG) and serum malondialdehyde-modified low-density lipoprotein (LDL) were decreased by efonidipine but unchanged by nifedipine. These results suggest that a T-type Ca2+ channel blocker, but not an L-type Ca2+ channel blocker, may improve vascular endothelial dysfunction in patients with essential hypertension via a reduction in oxidative stress." @default.
- W1987488246 created "2016-06-24" @default.
- W1987488246 creator A5004290927 @default.
- W1987488246 creator A5009828327 @default.
- W1987488246 creator A5018758307 @default.
- W1987488246 creator A5030507175 @default.
- W1987488246 creator A5063905870 @default.
- W1987488246 creator A5067907741 @default.
- W1987488246 creator A5072801244 @default.
- W1987488246 creator A5078318291 @default.
- W1987488246 creator A5078522754 @default.
- W1987488246 creator A5085689483 @default.
- W1987488246 date "2005-01-01" @default.
- W1987488246 modified "2023-10-12" @default.
- W1987488246 title "Beneficial Effect of T-Type Calcium Channel Blockers on Endothelial Function in Patients with Essential Hypertension" @default.
- W1987488246 cites W1555489744 @default.
- W1987488246 cites W1967097268 @default.
- W1987488246 cites W1968309124 @default.
- W1987488246 cites W1975677471 @default.
- W1987488246 cites W1983128983 @default.
- W1987488246 cites W1989593519 @default.
- W1987488246 cites W1995477662 @default.
- W1987488246 cites W2012607597 @default.
- W1987488246 cites W2017762784 @default.
- W1987488246 cites W2025175696 @default.
- W1987488246 cites W2037417530 @default.
- W1987488246 cites W2046176923 @default.
- W1987488246 cites W2048493616 @default.
- W1987488246 cites W2063074529 @default.
- W1987488246 cites W2064729923 @default.
- W1987488246 cites W2073353638 @default.
- W1987488246 cites W2080696801 @default.
- W1987488246 cites W2088955890 @default.
- W1987488246 cites W2089258822 @default.
- W1987488246 cites W2110993458 @default.
- W1987488246 cites W2116129188 @default.
- W1987488246 cites W2123861048 @default.
- W1987488246 cites W2137704829 @default.
- W1987488246 cites W2143977823 @default.
- W1987488246 cites W2145508023 @default.
- W1987488246 cites W2163958661 @default.
- W1987488246 cites W2170036768 @default.
- W1987488246 cites W2324841714 @default.
- W1987488246 cites W2341645956 @default.
- W1987488246 doi "https://doi.org/10.1291/hypres.28.889" @default.
- W1987488246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16555577" @default.
- W1987488246 hasPublicationYear "2005" @default.
- W1987488246 type Work @default.
- W1987488246 sameAs 1987488246 @default.
- W1987488246 citedByCount "54" @default.
- W1987488246 countsByYear W19874882462012 @default.
- W1987488246 countsByYear W19874882462013 @default.
- W1987488246 countsByYear W19874882462014 @default.
- W1987488246 countsByYear W19874882462015 @default.
- W1987488246 countsByYear W19874882462016 @default.
- W1987488246 countsByYear W19874882462017 @default.
- W1987488246 countsByYear W19874882462019 @default.
- W1987488246 countsByYear W19874882462020 @default.
- W1987488246 countsByYear W19874882462021 @default.
- W1987488246 countsByYear W19874882462022 @default.
- W1987488246 countsByYear W19874882462023 @default.
- W1987488246 crossrefType "journal-article" @default.
- W1987488246 hasAuthorship W1987488246A5004290927 @default.
- W1987488246 hasAuthorship W1987488246A5009828327 @default.
- W1987488246 hasAuthorship W1987488246A5018758307 @default.
- W1987488246 hasAuthorship W1987488246A5030507175 @default.
- W1987488246 hasAuthorship W1987488246A5063905870 @default.
- W1987488246 hasAuthorship W1987488246A5067907741 @default.
- W1987488246 hasAuthorship W1987488246A5072801244 @default.
- W1987488246 hasAuthorship W1987488246A5078318291 @default.
- W1987488246 hasAuthorship W1987488246A5078522754 @default.
- W1987488246 hasAuthorship W1987488246A5085689483 @default.
- W1987488246 hasBestOaLocation W19874882461 @default.
- W1987488246 hasConcept C120770815 @default.
- W1987488246 hasConcept C126322002 @default.
- W1987488246 hasConcept C134018914 @default.
- W1987488246 hasConcept C153461711 @default.
- W1987488246 hasConcept C2776151105 @default.
- W1987488246 hasConcept C2777097880 @default.
- W1987488246 hasConcept C2777604165 @default.
- W1987488246 hasConcept C2778401633 @default.
- W1987488246 hasConcept C2779066535 @default.
- W1987488246 hasConcept C2780356492 @default.
- W1987488246 hasConcept C2780972559 @default.
- W1987488246 hasConcept C519063684 @default.
- W1987488246 hasConcept C71924100 @default.
- W1987488246 hasConcept C84393581 @default.
- W1987488246 hasConcept C85520022 @default.
- W1987488246 hasConcept C98274493 @default.
- W1987488246 hasConceptScore W1987488246C120770815 @default.
- W1987488246 hasConceptScore W1987488246C126322002 @default.
- W1987488246 hasConceptScore W1987488246C134018914 @default.
- W1987488246 hasConceptScore W1987488246C153461711 @default.
- W1987488246 hasConceptScore W1987488246C2776151105 @default.
- W1987488246 hasConceptScore W1987488246C2777097880 @default.
- W1987488246 hasConceptScore W1987488246C2777604165 @default.
- W1987488246 hasConceptScore W1987488246C2778401633 @default.
- W1987488246 hasConceptScore W1987488246C2779066535 @default.