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- W1987497429 abstract "The human brain contains large concentrations of folic acid (FA) (Reynolds 1976), and deficiencies of this vitamin may be associated with both neurological (Reynolds 1976; Shorvon et al. 1980) and psychiatric disorders (Camey 1979; Botez et al. 1982; Abou-Saleh and Coppen 1986). Furthermore, when severe enough to be associated with meg~ob~astic anemia, FA deficiency may also result in reversible dementia (Botez et al. 1982; Lishman 1978). The biochemical role of FA in cognitive function is unclear, but it is known that the vitamin is important in the synthesis of norepinephrine (NE), dopamine (DA), and serotonin (5HT) (Turner 1979). Specifically, FA may be required for tyrosine hydroxylase to act in the rate-limiting step of DA and NE synthesis (Turner 1979). A deficiency of FA in rats has also been associated with a decrease in brain 5-HT levels, implying a role for FA in the synthesis or metabolism of this monoamine as well (Botez et al. 1979). DA, NE, and 5-HT are all thought to be important modulators of attentional and higher order memory functions (Woikowitz et" @default.
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- W1987497429 date "1988-07-01" @default.
- W1987497429 modified "2023-09-23" @default.
- W1987497429 title "RBC folic acid levels and cognitive performance in elderly patients: A preliminary report" @default.
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- W1987497429 doi "https://doi.org/10.1016/0006-3223(88)90207-7" @default.
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