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- W1987502015 abstract "OBJECTIVE: It has been previously reported that infertile patients have higher frequency of abnormal DNA methylation on imprinted loci than fertile controls. Additionally, we have recently shown that sperm from fertile men have a unique pattern of epigenetic modifications that may “poise” sperm genes for expression in early embryogenesis. These and other studies have highlighted the potential role of epigenetic control during spermatogenesis and subsequent sperm function. The aim of this pilot study was to evaluate sperm from infertile men for possible changes in the methylation pattern of the promoter regions of genes that are involved in early development (MIR17, HOXC11) and transcription factors (OCT4, SOX2, NANOG)." @default.
- W1987502015 created "2016-06-24" @default.
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- W1987502015 creator A5087333301 @default.
- W1987502015 date "2009-09-01" @default.
- W1987502015 modified "2023-10-16" @default.
- W1987502015 title "The methylation status of the promoters of the OCT4, SOX2, HOXC11, MIR17 and NANOG genes in infertile men" @default.
- W1987502015 doi "https://doi.org/10.1016/j.fertnstert.2009.07.1485" @default.
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