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- W1987515103 abstract "2A is an oligopeptide sequence mediating a ribosome 'skipping' effect, producing an apparent 'cleavage' of polyproteins. First identified and characterized in picornaviruses, '2A-like' sequences are found in other mammalian viruses and a wide range of insect viruses. Databases were analysed using a motif conserved amongst 2A/2A-like sequences. The newly identified 2A-like sequences (30 aa) were inserted into a reporter polyprotein to determine their cleavage activity. Our analyses showed that these sequences fall into two categories. The majority mediated very high (complete) cleavage to separate proteins and a few sequences mediated cleavage with lower efficiency, generating appreciable levels of the uncleaved form. Phylogenetic analyses of 2A-like sequences and RNA-dependent RNA polymerases (RdRps) indicated multiple, independent, acquisitions of these sequences at different stages during virus evolution. Within a virus family, 2A sequences are (probably) homologous, but diverge due to other evolutionary pressures. Amongst different families, however, 2A/2A-like sequences appear to be homoplasic." @default.
- W1987515103 created "2016-06-24" @default.
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- W1987515103 date "2008-04-01" @default.
- W1987515103 modified "2023-10-16" @default.
- W1987515103 title "Occurrence, function and evolutionary origins of ‘2A-like’ sequences in virus genomes" @default.
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- W1987515103 doi "https://doi.org/10.1099/vir.0.83428-0" @default.
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