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• W1987529029 abstract "PRIMARY tumors of the thymus, as a group, have not been recognized clinically in as large numbers, in the past, as they should have been if all the diagnostic measures had been employed. A perusal of the literature of this subject discloses the fact that a large percentage of the cases came to the autopsy table without a correct diagnosis having been made and many of the cases had not even had a roentgenographic study of the chest. Much of the literature is concerned with discussion of the pathology of these tumors, especially as to the origin of the small lymphocyte-like cells found in the parenchyma. This uncertainty as to the exact origin of these cells has led to the word “thymoma” being employed to designate certain tumors which in general resemble lymphosarcomata. These tumors are relatively uncommon but apparently not so rare as the literature would indicate. Approximately one hundred cases of primary thymic tumors have been reported, of which less than twenty were carcinomata and practically all the remainder were sarcomata. Anatomy The thymus is a paired organ arising from the third bronchial clefts. It occupies the anterior and superior mediastinum and varies in size according to the age and general condition of the health. It may be so large as to fill the available space between the pleural sacs laterally, the sternum anteriorly, and the pericardium and great vessels posteriorly. On the other hand, it may be so small that it is found with difficulty at the postmortem table. Its shape is determined by its size and by the structures with which it is in intimate contact. There is a fibrous capsule which sends septa into the substance of the gland, thus dividing it into lobules which are, in turn, subdivided into follicles. These follicles consist of medulla and cortex. The structure of the cortex resembles lymph gland structure, except that the reticulum instead of being fibrous is syncytial. The spaces of the reticulum are crowded with lymphocytes. The medulla resembles the cortex, but the reticulum is coarser and contains cell nests, the concentric corpuscles of Hassall. Pathology Primary thymic tumors, according to Ewing (1), may be classified as follows: (1) Lymphosarcoma or thymoma, composed of a diffuse growth of round, polyhedral, and giant cells. The chief source of this tumor is probably the reticulum cell, but lymphocytes are often present in abundance. (2) Carcinoma arising from the reticulum cells. (3) To these may be added very rare and somewhat questionable cases of tumors attributed to the stroma and called spindle-cell or myxosarcoma. When the chest is opened at the postmortem table a mass is seen occupying the region of the thymus. This may be round or triangular in shape, lying in the anterior mediastinum, and is usually yellowish or grayish in color. It may be encapsulated but is frequently adherent to the sternum and surrounding organs, and may invade the pericardium, pleura, lungs, trachea, and glands." @default.
• W1987529029 created "2016-06-24" @default.
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• W1987529029 date "1930-03-01" @default.
• W1987529029 modified "2023-09-26" @default.
• W1987529029 title "Roentgen Diagnosis and Treatment of Thymomata" @default.
• W1987529029 doi "https://doi.org/10.1148/14.3.267" @default.
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