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- W1987540129 abstract "Signaling pathways belong to a complex system of communication that governs cellular processes. They represent signal transduction from an extracellular stimulus via a receptor to intracellular mediators, as well as intracellular interactions. Perturbations in signaling cascade often lead to detrimental changes in cell function and cause many diseases, including cancer. Identification of deregulated pathways may advance the understanding of complex diseases and lead to improvement of therapeutic strategies. We propose Analysis of Consistent Signal Transduction (ACST), a novel method for analysis of signaling pathways. Our method incorporates information regarding pathway topology, as well as data on the position of every gene in each pathway. To preserve gene-gene interactions we use a subject-sampling permutation model to assess the significance of pathway perturbations. We applied our approach to nine independent datasets of global gene expression profiling. The results of ACST, as well as three other methods used to analyze signaling pathways, are presented in the context of biological significance and repeatability among similar, yet independent, datasets. We demonstrate the usefulness of using information of pathway structure as well as genes' functions in the analysis of signaling pathways. We also show that ACST leads to biologically meaningful results and high repeatability." @default.
- W1987540129 created "2016-06-24" @default.
- W1987540129 creator A5032104235 @default.
- W1987540129 creator A5033742662 @default.
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- W1987540129 date "2012-07-25" @default.
- W1987540129 modified "2023-09-27" @default.
- W1987540129 title "Identification of Pathway Deregulation – Gene Expression Based Analysis of Consistent Signal Transduction" @default.
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- W1987540129 doi "https://doi.org/10.1371/journal.pone.0041541" @default.
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- W1987540129 hasPublicationYear "2012" @default.
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