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- W1987542468 abstract "The conformational properties of a series of gastrin-related peptides in aqueous solution and in 2,2,2-trifluoroethanol (TFE) have been investigated by CD measurements. In aqueous solution the peptides Leu32-HG-34 (human big gastrin), Nle15-HG-17 (human little gastrin), and Nle11-HG-13 assume a random-coil structure in the pH range 3–7. In TFE the three hormones fold into partially ordered structures, consisting of mixtures of α-helix, β-form and random coil. Comparison with the CD properties of the shorter gastrin peptides HG-4 (tetragastrin), Nα-Boc-HG-5 (pentagastrin), and HG-7 (heptagastrin) indicates that the biologically important C-terminal sequence Trp-Met-Asp-Phe-NH2 in TFE does not maintain the same geometry upon elongation of the chain at the N-terminus from 4 to 34 residues. Thus, the various conformations in solution of the gastrin peptides examined do not provide a structural explanation for their very similar biological activity. Therefore, we hypothesize that the C-terminal tetrapeptide amide folds into an “active” structure only upon interaction with the receptor." @default.
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- W1987542468 date "1981-04-01" @default.
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- W1987542468 title "Conformational aspects of gastrin-related peptides: A circular dichroism study" @default.
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- W1987542468 doi "https://doi.org/10.1002/bip.1981.360200402" @default.
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