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• W1987548761 abstract "Despite the vast number of techniques developed for the cyclization of small peptides, cyclization efficiency remains problematic in peptides that lack turn-promoting structures. Here we demonstrate the utility of click chemistry as a macrocyclization tool in the solid-phase synthesis of cyclic tetra-, penta-, hexa-, and heptapeptides. On-resin cyclization is completed at room temperature within 6 h, resulting in predominantly monomer with small amounts of cyclomultimer byproducts." @default.
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• W1987548761 date "2007-10-23" @default.
• W1987548761 modified "2023-09-25" @default.
• W1987548761 title "Click Chemistry as a Macrocyclization Tool in the Solid-Phase Synthesis of Small Cyclic Peptides" @default.
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• W1987548761 doi "https://doi.org/10.1021/ol702228u" @default.
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