FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987548773> ?p ?o ?g. }

• W1987548773 endingPage "e26177" @default.
• W1987548773 startingPage "e26177" @default.
• W1987548773 abstract "Insulin-like growth factor (IGF) signaling through human insulin receptor isoform A (IR-A) contributes to tumorigenesis and intrinsic resistance to anti-IGF1R therapy. In the present study, we (a) developed quantitative TaqMan real time-PCR-based assays (qRT-PCR) to measure human insulin receptor isoforms with high specificity, (b) evaluated isoform expression levels in molecularly-defined breast cancer subtypes, and (c) identified the IR-A:IR-B mRNA ratio as a potential biomarker guiding patient stratification for anti-IGF therapies.mRNA expression levels of IR-A and IR-B were measured in 42 primary breast cancers and 19 matched adjacent normal tissues with TaqMan qRT-PCR assays. The results were further confirmed in 165 breast cancers. The tumor samples were profiled using whole genome microarrays and subsequently subtyped using the PAM50 breast cancer gene signature. The relationship between the IR-A:IR-B ratio and cancer subtype, as well as markers of proliferation were characterized.The mRNA expression levels of IR-A in the breast tumors were similar to those observed in the adjacent normal tissues, while the mRNA levels of IR-B were significantly decreased in tumors. The IR-A:IR-B ratio was significantly higher in luminal B breast cancer than in luminal A. Strong concordance between the IR-A:IR-B ratio and the composite Oncotype DX proliferation score was observed for stratifying the latter two breast cancer subtypes.The reduction in IR-B expression is the key to the altered IR-A:IR-B ratio observed in breast cancer. The IR-A:IR-B ratio may have biomarker utility in guiding a patient stratification strategy for an anti-IGF therapeutic." @default.
• W1987548773 created "2016-06-24" @default.
• W1987548773 creator A5007107739 @default.
• W1987548773 creator A5009504777 @default.
• W1987548773 creator A5011703930 @default.
• W1987548773 creator A5013644412 @default.
• W1987548773 creator A5024440200 @default.
• W1987548773 creator A5024465677 @default.
• W1987548773 creator A5041737552 @default.
• W1987548773 creator A5043257116 @default.
• W1987548773 creator A5044150390 @default.
• W1987548773 creator A5050252155 @default.
• W1987548773 creator A5056194172 @default.
• W1987548773 creator A5066301151 @default.
• W1987548773 creator A5071837295 @default.
• W1987548773 creator A5080636708 @default.
• W1987548773 creator A5082831559 @default.
• W1987548773 date "2011-10-26" @default.
• W1987548773 modified "2023-09-27" @default.
• W1987548773 title "Altered Expression of Insulin Receptor Isoforms in Breast Cancer" @default.
• W1987548773 cites W1871669466 @default.
• W1987548773 cites W1919421236 @default.
• W1987548773 cites W1965602606 @default.
• W1987548773 cites W1984532045 @default.
• W1987548773 cites W1996920020 @default.
• W1987548773 cites W2005890897 @default.
• W1987548773 cites W2007962443 @default.
• W1987548773 cites W2028236537 @default.
• W1987548773 cites W2033478817 @default.
• W1987548773 cites W2054371666 @default.
• W1987548773 cites W2058639493 @default.
• W1987548773 cites W2061380019 @default.
• W1987548773 cites W2063253920 @default.
• W1987548773 cites W2070299552 @default.
• W1987548773 cites W2072772580 @default.
• W1987548773 cites W2074465378 @default.
• W1987548773 cites W2081081119 @default.
• W1987548773 cites W2083374924 @default.
• W1987548773 cites W2089171551 @default.
• W1987548773 cites W2097255042 @default.
• W1987548773 cites W2099025205 @default.
• W1987548773 cites W2105882193 @default.
• W1987548773 cites W2127057139 @default.
• W1987548773 cites W2128985829 @default.
• W1987548773 cites W2132619562 @default.
• W1987548773 cites W2137879576 @default.
• W1987548773 cites W2145355816 @default.
• W1987548773 cites W2145552137 @default.
• W1987548773 cites W2155045799 @default.
• W1987548773 cites W2281869076 @default.
• W1987548773 cites W70929705 @default.
• W1987548773 doi "https://doi.org/10.1371/journal.pone.0026177" @default.
• W1987548773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3202518" @default.
• W1987548773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22046260" @default.
• W1987548773 hasPublicationYear "2011" @default.
• W1987548773 type Work @default.
• W1987548773 sameAs 1987548773 @default.
• W1987548773 citedByCount "49" @default.
• W1987548773 countsByYear W19875487732012 @default.
• W1987548773 countsByYear W19875487732013 @default.
• W1987548773 countsByYear W19875487732014 @default.
• W1987548773 countsByYear W19875487732015 @default.
• W1987548773 countsByYear W19875487732016 @default.
• W1987548773 countsByYear W19875487732017 @default.
• W1987548773 countsByYear W19875487732018 @default.
• W1987548773 countsByYear W19875487732019 @default.
• W1987548773 countsByYear W19875487732020 @default.
• W1987548773 countsByYear W19875487732021 @default.
• W1987548773 countsByYear W19875487732022 @default.
• W1987548773 countsByYear W19875487732023 @default.
• W1987548773 crossrefType "journal-article" @default.
• W1987548773 hasAuthorship W1987548773A5007107739 @default.
• W1987548773 hasAuthorship W1987548773A5009504777 @default.
• W1987548773 hasAuthorship W1987548773A5011703930 @default.
• W1987548773 hasAuthorship W1987548773A5013644412 @default.
• W1987548773 hasAuthorship W1987548773A5024440200 @default.
• W1987548773 hasAuthorship W1987548773A5024465677 @default.
• W1987548773 hasAuthorship W1987548773A5041737552 @default.
• W1987548773 hasAuthorship W1987548773A5043257116 @default.
• W1987548773 hasAuthorship W1987548773A5044150390 @default.
• W1987548773 hasAuthorship W1987548773A5050252155 @default.
• W1987548773 hasAuthorship W1987548773A5056194172 @default.
• W1987548773 hasAuthorship W1987548773A5066301151 @default.
• W1987548773 hasAuthorship W1987548773A5071837295 @default.
• W1987548773 hasAuthorship W1987548773A5080636708 @default.
• W1987548773 hasAuthorship W1987548773A5082831559 @default.
• W1987548773 hasBestOaLocation W19875487731 @default.
• W1987548773 hasConcept C104317684 @default.
• W1987548773 hasConcept C112446052 @default.
• W1987548773 hasConcept C121608353 @default.
• W1987548773 hasConcept C126322002 @default.
• W1987548773 hasConcept C134018914 @default.
• W1987548773 hasConcept C143660080 @default.
• W1987548773 hasConcept C160798450 @default.
• W1987548773 hasConcept C2777391703 @default.
• W1987548773 hasConcept C2779306644 @default.
• W1987548773 hasConcept C2781197716 @default.
• W1987548773 hasConcept C48023723 @default.

• next