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- W1987552345 endingPage "CCRPM.S10592" @default.
- W1987552345 startingPage "CCRPM.S10592" @default.
- W1987552345 abstract "Repeated bouts of acute and chronic lung infections are responsible for progressive pulmonary function decline in individuals with cystic fibrosis (CF), ultimately leading to respiratory failure and death. Pseudomonas aeruginosa is the archetypical CF pathogen, causes chronic infection in 70% of individuals, and is associated with an accelerated clinical decline. The management of P. aeruginosa in CF has been revolutionized with the development and widespread use of inhaled antibiotics. Aerosol delivery of antimicrobial compounds in CF enables extremely high concentrations of antibiotics to be reached directly at the site of infection potentially overcoming adaptive resistance and avoiding the potential for cumulative systemic toxicities. Tobramycin inhalation powder (TIP) represents the first dry powder inhaled (DPI) antibiotic available for use in CF. DPIs are notable for a markedly reduced time for administration, ease of portability, and increased compliance. TIP has been developed as a therapeutic alternative to tobramycin inhalation solution (TIS), the standard of care for the past 20 years within CF. Relative to TIS 300 mg nebulized twice daily in on-and-off cycles of 28 days duration, TIP 112 mg twice daily via the T-326 inhaler administered on the same schedule is associated with marked time savings, increased patient satisfaction, and comparable clinical end points. TIP represents an innovative treatment strategy for those individuals with CF and holds the promise of increased patient compliance and thus the potential for improved clinical outcomes." @default.
- W1987552345 created "2016-06-24" @default.
- W1987552345 creator A5018415162 @default.
- W1987552345 creator A5030298339 @default.
- W1987552345 creator A5063583896 @default.
- W1987552345 date "2013-01-01" @default.
- W1987552345 modified "2023-10-16" @default.
- W1987552345 title "Tobramycin Inhalation Powder (TIP): An Efficient Treatment Strategy for the Management of Chronic <i>Pseudomonas Aeruginosa</i> Infection in Cystic Fibrosis" @default.
- W1987552345 cites W137803055 @default.
- W1987552345 cites W1504654291 @default.
- W1987552345 cites W1578065770 @default.
- W1987552345 cites W1879460511 @default.
- W1987552345 cites W1882728533 @default.
- W1987552345 cites W1901312711 @default.
- W1987552345 cites W1963648289 @default.
- W1987552345 cites W1971558827 @default.
- W1987552345 cites W1975379303 @default.
- W1987552345 cites W1976264709 @default.
- W1987552345 cites W1977640666 @default.
- W1987552345 cites W1980261773 @default.
- W1987552345 cites W1983638164 @default.
- W1987552345 cites W1984893629 @default.
- W1987552345 cites W1988324912 @default.
- W1987552345 cites W1997220729 @default.
- W1987552345 cites W2010268034 @default.
- W1987552345 cites W2014673448 @default.
- W1987552345 cites W2015720649 @default.
- W1987552345 cites W2020366537 @default.
- W1987552345 cites W2020684336 @default.
- W1987552345 cites W2020767671 @default.
- W1987552345 cites W2025126892 @default.
- W1987552345 cites W2027464873 @default.
- W1987552345 cites W2028213520 @default.
- W1987552345 cites W2029193333 @default.
- W1987552345 cites W2030602816 @default.
- W1987552345 cites W2032940647 @default.
- W1987552345 cites W2034055729 @default.
- W1987552345 cites W2036744146 @default.
- W1987552345 cites W2048055596 @default.
- W1987552345 cites W2048478051 @default.
- W1987552345 cites W2054492134 @default.
- W1987552345 cites W2055117023 @default.
- W1987552345 cites W2055857822 @default.
- W1987552345 cites W2056888152 @default.
- W1987552345 cites W2057418340 @default.
- W1987552345 cites W2058889783 @default.
- W1987552345 cites W2062652176 @default.
- W1987552345 cites W2067893324 @default.
- W1987552345 cites W2070458418 @default.
- W1987552345 cites W2071842858 @default.
- W1987552345 cites W2075069205 @default.
- W1987552345 cites W2076782896 @default.
- W1987552345 cites W2078186052 @default.
- W1987552345 cites W2081500562 @default.
- W1987552345 cites W2081889668 @default.
- W1987552345 cites W2083699604 @default.
- W1987552345 cites W2085903904 @default.
- W1987552345 cites W2085940681 @default.
- W1987552345 cites W2088377627 @default.
- W1987552345 cites W2088849723 @default.
- W1987552345 cites W2095333109 @default.
- W1987552345 cites W2096779618 @default.
- W1987552345 cites W2097575804 @default.
- W1987552345 cites W2098093150 @default.
- W1987552345 cites W2100164793 @default.
- W1987552345 cites W2105374673 @default.
- W1987552345 cites W2105915947 @default.
- W1987552345 cites W2107189796 @default.
- W1987552345 cites W2109399497 @default.
- W1987552345 cites W2110828250 @default.
- W1987552345 cites W2111786217 @default.
- W1987552345 cites W2113263701 @default.
- W1987552345 cites W2114399980 @default.
- W1987552345 cites W2115486016 @default.
- W1987552345 cites W2116030030 @default.
- W1987552345 cites W2117064229 @default.
- W1987552345 cites W2119770598 @default.
- W1987552345 cites W2125167507 @default.
- W1987552345 cites W2126192952 @default.
- W1987552345 cites W2127490249 @default.
- W1987552345 cites W2130878552 @default.
- W1987552345 cites W2133531226 @default.
- W1987552345 cites W2134135997 @default.
- W1987552345 cites W2144317224 @default.
- W1987552345 cites W2149520619 @default.
- W1987552345 cites W2150906077 @default.
- W1987552345 cites W2152099509 @default.
- W1987552345 cites W2152321550 @default.
- W1987552345 cites W2153102800 @default.
- W1987552345 cites W2165501216 @default.
- W1987552345 cites W2165983822 @default.
- W1987552345 cites W2167293877 @default.
- W1987552345 cites W2169800903 @default.
- W1987552345 cites W2170955636 @default.
- W1987552345 cites W2171214880 @default.
- W1987552345 cites W2171230591 @default.
- W1987552345 cites W2171642430 @default.
- W1987552345 cites W2317332612 @default.