FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987559635> ?p ?o ?g. }

• W1987559635 endingPage "47" @default.
• W1987559635 startingPage "47" @default.
• W1987559635 abstract "Schizophrenia is a chronic disease of global importance. The second-generation antipsychotic quetiapine has a favorable side-effect profile, however, its clinical effectiveness has been called into question when compared with first-generation antipsychotics such as haloperidol. This study evaluates the efficacy and tolerability of quetiapine versus haloperidol for first-episode schizophrenia in the outpatient setting.156 adult patients with first-episode schizophrenia participated in an outpatient clinical trial and were randomized to quetiapine (200 mg/d; n = 78) or haloperidol (5 mg/d; n = 78). The study medications were titrated to a mean daily dose of 705 mg for quetiapeine and 14 mg for haloperidol. The patients were assessed at baseline, six weeks, and twelve weeks. The primary outcome measures were positive and negative scores of the Positive and Negative Syndrome Scale (PANSS). Secondary measures were Global Assessment of Functioning (GAF) scale for overall psychosocial functioning, and Simpson-Angus Scale (SAS) for extra-pyramidal symptoms.At twelve weeks, the quetiapine group had a greater decrease in PANSS positive (18.9 vs. 15.3, p = 0.013) and negative scores (15.5 vs. 11.6, p = 0.012), however, haloperidol showed a greater decrease in general psychopathology score (23.8 vs. 27.7, p = 0.012). No significant difference between groups were found for total PANSS (58.3 vs. 54.8, p = 0.24) and GAF (45.7 vs. 46.2, p = 0.79).ANOVA identified significant group interactions on PANSS positive (F = 18.72, df = 1.6,52.4, p < 0.0001), negative (F = 5.20, df = 1.1,35.7, p < 0.0001), depression/anxiety (F = 106.49, df = 1.14,37.8, p < 0.0001), and total scores (F = 7.51, df = 1.4,45.6, p = 0.001).SAS (8.62 vs. 0.26, p < 0.0001) and adverse events of akathisia (78% vs. 0%, p = 0.000), parkinsonism (66.6% vs. 0%, p < 0.0001), and fatigue (84.6% vs. 66.6%, p = 0.009) were greater in haloperidol compared to quetiapine, whereas headache was more common in quetiapine treated patients (11.5% vs. 35.9%, p < 0.0001).Quetiapine has greater efficacy for positive and negative symptoms with less extra-pyramidal symptoms than haloperidol when used for first-episode schizophrenia in the outpatient setting." @default.
• W1987559635 created "2016-06-24" @default.
• W1987559635 creator A5014385320 @default.
• W1987559635 creator A5027591575 @default.
• W1987559635 creator A5039610651 @default.
• W1987559635 creator A5047279084 @default.
• W1987559635 creator A5063743858 @default.
• W1987559635 creator A5073476826 @default.
• W1987559635 creator A5079941092 @default.
• W1987559635 date "2013-01-01" @default.
• W1987559635 modified "2023-10-14" @default.
• W1987559635 title "Efficacy and tolerability of quetiapine versus haloperidol in first-episode schizophrenia: a randomized clinical trial" @default.
• W1987559635 cites W1588915767 @default.
• W1987559635 cites W1963531680 @default.
• W1987559635 cites W1988482389 @default.
• W1987559635 cites W1989320180 @default.
• W1987559635 cites W1990084913 @default.
• W1987559635 cites W1993402347 @default.
• W1987559635 cites W1995760805 @default.
• W1987559635 cites W2060802427 @default.
• W1987559635 cites W2069831796 @default.
• W1987559635 cites W2100475473 @default.
• W1987559635 cites W2108607967 @default.
• W1987559635 cites W2115115146 @default.
• W1987559635 cites W2124552233 @default.
• W1987559635 cites W2139948598 @default.
• W1987559635 cites W2140606211 @default.
• W1987559635 cites W2159039084 @default.
• W1987559635 cites W2162089381 @default.
• W1987559635 cites W2169114246 @default.
• W1987559635 cites W2317259777 @default.
• W1987559635 cites W2916950229 @default.
• W1987559635 cites W4253924106 @default.
• W1987559635 doi "https://doi.org/10.1186/1755-7682-6-47" @default.
• W1987559635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4174907" @default.
• W1987559635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24308507" @default.
• W1987559635 hasPublicationYear "2013" @default.
• W1987559635 type Work @default.
• W1987559635 sameAs 1987559635 @default.
• W1987559635 citedByCount "11" @default.
• W1987559635 countsByYear W19875596352014 @default.
• W1987559635 countsByYear W19875596352015 @default.
• W1987559635 countsByYear W19875596352017 @default.
• W1987559635 countsByYear W19875596352019 @default.
• W1987559635 countsByYear W19875596352020 @default.
• W1987559635 countsByYear W19875596352021 @default.
• W1987559635 countsByYear W19875596352022 @default.
• W1987559635 crossrefType "journal-article" @default.
• W1987559635 hasAuthorship W1987559635A5014385320 @default.
• W1987559635 hasAuthorship W1987559635A5027591575 @default.
• W1987559635 hasAuthorship W1987559635A5039610651 @default.
• W1987559635 hasAuthorship W1987559635A5047279084 @default.
• W1987559635 hasAuthorship W1987559635A5063743858 @default.
• W1987559635 hasAuthorship W1987559635A5073476826 @default.
• W1987559635 hasAuthorship W1987559635A5079941092 @default.
• W1987559635 hasBestOaLocation W19875596351 @default.
• W1987559635 hasConcept C118552586 @default.
• W1987559635 hasConcept C126322002 @default.
• W1987559635 hasConcept C168563851 @default.
• W1987559635 hasConcept C197934379 @default.
• W1987559635 hasConcept C2776412080 @default.
• W1987559635 hasConcept C2778375690 @default.
• W1987559635 hasConcept C2779727114 @default.
• W1987559635 hasConcept C2780135775 @default.
• W1987559635 hasConcept C2780200951 @default.
• W1987559635 hasConcept C2780494398 @default.
• W1987559635 hasConcept C2780634440 @default.
• W1987559635 hasConcept C2780948584 @default.
• W1987559635 hasConcept C513476851 @default.
• W1987559635 hasConcept C71924100 @default.
• W1987559635 hasConceptScore W1987559635C118552586 @default.
• W1987559635 hasConceptScore W1987559635C126322002 @default.
• W1987559635 hasConceptScore W1987559635C168563851 @default.
• W1987559635 hasConceptScore W1987559635C197934379 @default.
• W1987559635 hasConceptScore W1987559635C2776412080 @default.
• W1987559635 hasConceptScore W1987559635C2778375690 @default.
• W1987559635 hasConceptScore W1987559635C2779727114 @default.
• W1987559635 hasConceptScore W1987559635C2780135775 @default.
• W1987559635 hasConceptScore W1987559635C2780200951 @default.
• W1987559635 hasConceptScore W1987559635C2780494398 @default.
• W1987559635 hasConceptScore W1987559635C2780634440 @default.
• W1987559635 hasConceptScore W1987559635C2780948584 @default.
• W1987559635 hasConceptScore W1987559635C513476851 @default.
• W1987559635 hasConceptScore W1987559635C71924100 @default.
• W1987559635 hasIssue "1" @default.
• W1987559635 hasLocation W19875596351 @default.
• W1987559635 hasLocation W19875596352 @default.
• W1987559635 hasLocation W19875596353 @default.
• W1987559635 hasLocation W19875596354 @default.
• W1987559635 hasOpenAccess W1987559635 @default.
• W1987559635 hasPrimaryLocation W19875596351 @default.
• W1987559635 hasRelatedWork W1538444209 @default.
• W1987559635 hasRelatedWork W1995185211 @default.
• W1987559635 hasRelatedWork W1997449074 @default.
• W1987559635 hasRelatedWork W2004906448 @default.
• W1987559635 hasRelatedWork W2032883400 @default.
• W1987559635 hasRelatedWork W2037190804 @default.
• W1987559635 hasRelatedWork W2047624323 @default.

• next