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- W1987566551 abstract "To predict the effect of antenatal ultrasound screening for congenital heart disease and maternal serum screening of Down's syndrome on the practice of paediatric cardiology and paediatric cardiac surgery.A retrospective and prospective ascertainment of all congenital heart disease diagnosed in infancy in 1985-1991.One English health region.All congenital heart disease diagnosed in infancy by echocardiography, cardiac catheterisation, surgery, or necropsy was classified as complex, significant, or minor and as detectable or not detectable on a routine antenatal ultrasound scan.1347 infants had congenital heart disease which was complex in 13%, significant in 55%, and minor in 32%. 15% of cases were detectable on routine antenatal ultrasound. Assuming 20% detection and termination of 67% of affected pregnancies, liveborn congenital heart disease would be reduced by 2%, infant mortality from congenital heart disease by 5%, and paediatric cardiac surgical activity by 3%. Maternal screening for Down's syndrome, assuming 75% uptake, 60% detection, and termination of all affected pregnancies, would reduce liveborn cases of Down's syndrome by 45%, liveborn cases of congenital heart disease by 3.5%, and cardiac surgery by 2.6%.Screening for congenital heart disease using the four chamber view in routine obstetric examinations and maternal serum screening for Down's syndrome is likely to have only a small effect on the requirements for paediatric cardiology services and paediatric cardiac surgery." @default.
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- W1987566551 title "Antenatal diagnosis of congenital heart disease and Down's syndrome: the potential effect on the practice of paediatric cardiology." @default.
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- W1987566551 doi "https://doi.org/10.1136/hrt.74.2.192" @default.
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