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- W1987579426 abstract "Expression of p53, K-ras, and proliferating cell nuclear antigen (PCNA) and mutations of p53 and K-ras genes in lung lesions of Han/Wistar rats were investigated by immunohistochemistry and direct DNA sequencing following a long-term exposure of animals to neutron-activated UO2 particles. The p53 protein was overexpressed in all five malignant tumors, in 62% of benign tumors, and in 42% of hyperplastic lesions examined. K-ras protein and PCNA levels were only slightly elevated in all types of lung lesions. In three malignant tumors a C-->T transition was detected in codon 288 (human 290) of the p53 gene, but this mutation was not present in seven other tumors analyzed. No mutations were detected in codons 12/13 and 61 of the K-ras gene in any of the five tumors analyzed. Our findings suggest that K-ras overexpression is a rare alteration, whereas p53 protein overexpression (sometimes associated with mutated p53 gene), as assessed with the CM5 antibody, is a relatively common phenomenon in hot particle-induced preneoplastic and neoplastic rat lung lesions." @default.
- W1987579426 created "2016-06-24" @default.
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- W1987579426 date "1999-05-01" @default.
- W1987579426 modified "2023-09-25" @default.
- W1987579426 title "Association of p53, K-ras and Proliferating Cell Nuclear Antigen with Rat Lung Lesions Following Exposure to Simulated Nuclear Fuel Particles" @default.
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- W1987579426 doi "https://doi.org/10.1046/j.1525-1500.1999.99026.x" @default.
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