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• W1987586275 abstract "Abstract Nineteen phenol anesthetics protected human erythrocytes from hypotonic hemolysis. The concentration for 50 % anti-hemolysis (AH 50 % ) ranged from 7.8 mM for phenol to 0.113 mM for 3-CH 3 -4-Cl phenol; the other substituents were 4-OCH 3 ; 4-F; 3-N(CH 3 ) 2 ; 4-COOCH 3 ; 3-NO 2 ; 3-CH 3 ; 4-OC 2 H 5 ; 4-CH 3 ; 2-Cl; 2,6-(CH 3 ) 2 ; 3,5-(CH 3 ) 2 ; 4-Cl; 2-CF 3 ; 4-Br; 2,4-Cl 2 ; 3-I and 4-tert.-C 4 H 9 . 1. 2. The coefficient of correlation between the AH 50 % concentrations and the octanol/water partition coefficients was very high (0.963), indicating a hydrophobic interaction between the membrane and the phenol anesthetic. The anti-hemolytic effect is associated with membrane expansion. The correlation between AH 50 % and p K a or Hammett σ constants was very low, suggesting a negligible role of charge in the interaction. 2. 3. The adsorption isotherms of 4-bromo-phenol, [ 14 C]phenol and 3-methyl, 4-chlorophenol to erythrocyte ghost membranes were obtained. The membrane/buffer partition coefficients of these phenols were independent of the free concentrations of the phenols. 3. 4. The membrane/buffer partition coefficient for each of the 3 phenols was about one-fifth of the value for the octanol/water partition coefficient. Since this factor of 5 also holds for other alcohols, it seemed justified to compute all the membrane/buffer partition coefficients directly from the octanol/buffer partition coefficients. Separate experiments indicated that the octanol/buffer and the octanol/water partition coefficients were identical. 4. 5. The membrane concentrations of the phenol anesthetics at 50 % anti-hemolysis ranged from 0.02 to 0.08 mole of anesthetic per kg dry membrane. The mean value for the membrane concentration was 0.04 mole/kg membrane, as predicted by the Meyer-Overton rule of anesthesia." @default.
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• W1987586275 date "1972-01-01" @default.
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• W1987586275 title "The hydrophobic expansion of erythrocyte membranes by the phenol anesthetics" @default.
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• W1987586275 doi "https://doi.org/10.1016/0005-2736(72)90020-x" @default.
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