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• W1987605367 abstract "<h3>Objective</h3> Helper T (Th) cell responses are critical for the pathogenesis of <i>Helicobacter pylori</i>-induced gastritis. Th22 cells represent a newly discovered Th cell subset, but their relevance to <i>H. pylori</i>-induced gastritis is unknown. <h3>Design</h3> Flow cytometry, real-time PCR and ELISA analyses were performed to examine cell, protein and transcript levels in gastric samples from patients and mice infected with <i>H. pylori</i>. Gastric tissues from interleukin (IL)-22-deficient and wild-type (control) mice were also examined. Tissue inflammation was determined for pro-inflammatory cell infiltration and pro-inflammatory protein production. Gastric epithelial cells and myeloid-derived suppressor cells (MDSC) were isolated, stimulated and/or cultured for Th22 cell function assays. <h3>Results</h3> Th22 cells accumulated in gastric mucosa of both patients and mice infected with <i>H. pylori</i>. Th22 cell polarisation was promoted via the production of IL-23 by dendritic cells (DC) during <i>H. pylori</i> infection, and resulted in increased inflammation within the gastric mucosa. This inflammation was characterised by the CXCR2-dependent influx of MDSCs, whose migration was induced via the IL-22-dependent production of CXCL2 by gastric epithelial cells. Under the influence of IL-22, MDSCs, in turn, produced pro-inflammatory proteins, such as S100A8 and S100A9, and suppressed Th1 cell responses, thereby contributing to the development of <i>H. pylori</i>-associated gastritis. <h3>Conclusions</h3> This study, therefore, identifies a novel regulatory network involving <i>H. pylori</i>, DCs, Th22 cells, gastric epithelial cells and MDSCs, which collectively exert a pro-inflammatory effect within the gastric microenvironment. Efforts to inhibit this Th22-dependent pathway may therefore prove a valuable strategy in the therapy of <i>H. pylori</i>-associated gastritis." @default.
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• W1987605367 date "2014-08-18" @default.
• W1987605367 modified "2023-10-17" @default.
• W1987605367 title "A pro-inflammatory role for Th22 cells in<i>Helicobacter pylori</i>-associated gastritis" @default.
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• W1987605367 doi "https://doi.org/10.1136/gutjnl-2014-307020" @default.
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