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- W1987613196 abstract "Recent advances in delineating the biological functions of p53 had shed the light on its key role in the multifacets of cellular homeostasis. After its activation, via DNA damage, oxidative stress, or aberrant expression of oncogenes, p53 transduces its classical effect through several mechanisms comprising activation of the DNA repair machinery, cell cycle arrest, and initiation of apoptosis or senescence. In the mammalian brain, p53 plays critical functions in normal development, tumor suppression, neurodegenerative diseases, and aging. Herein, we focus on the constitutive pro-oxidant activity of p53 in neurons and discuss the potential implication of this finding in the context of neurodegenerative diseases and normal brain aging." @default.
- W1987613196 created "2016-06-24" @default.
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- W1987613196 date "2011-09-15" @default.
- W1987613196 modified "2023-09-26" @default.
- W1987613196 title "p53 Pro-Oxidant Activity in the Central Nervous System: Implication in Aging and Neurodegenerative Diseases" @default.
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- W1987613196 doi "https://doi.org/10.1089/ars.2010.3610" @default.
- W1987613196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20849375" @default.
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