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- W1987616871 abstract "Recently the function of the sirtuin family, named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2), has received a lot of attention, as their beneficial impact on longevity was linked to their effects on metabolic control. All sirtuins require nicotinamide adenine dinucleotide (NAD + ) for their deacetylase or ADP‐ribosyl transferase activity, linking their function tightly to cellular energy levels. SIRT1, the founding member of the sirtuin family, modulates many aspects of glucose and lipid homeostasis in almost all key metabolic tissues. Other members including SIRT2, SIRT3, and SIRT4 are also implicated in various metabolic processes. Here, we review the recent data related to the role of sirtuins in the control of metabolic homeostasis and possible underlying molecular mechanisms." @default.
- W1987616871 created "2016-06-24" @default.
- W1987616871 creator A5003154600 @default.
- W1987616871 creator A5021649597 @default.
- W1987616871 date "2009-09-01" @default.
- W1987616871 modified "2023-10-15" @default.
- W1987616871 title "The Role of Sirtuins in the Control of Metabolic Homeostasis" @default.
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- W1987616871 doi "https://doi.org/10.1111/j.1749-6632.2009.04952.x" @default.
- W1987616871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3620552" @default.
- W1987616871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19751409" @default.
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