Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987629465> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1987629465 endingPage "221" @default.
- W1987629465 startingPage "218" @default.
- W1987629465 abstract "Premature ovarian failure (POF) is defined as an amenorrhea for more than 4months, associated with elevated gonadotropins, usually higher than 20mIU/ml, occurring in a woman before the age of 40. Some candidate genes have been identified in the past 15years, such as FOXL2, FSHR, BMP15, GDF9, Xfra premutation. However, POF etiology remains unknown in more than 90% of cases. The first strategy to identify candidate gene, apart from studying genes involved in ovarian failure in animal models, relies on the study of X chromosome deletions and X;autosome translocations in patients. The second strategy is based on linkage analysis, the third one on Comparative Genomic Hybridization (CGH) array. The latest strategy relies on Genome-Wide Association Studies (GWAS). This technique consists in screening single nucleotide polymorphisms (SNPs) in patients and controls. So far, three studies have been performed and have identified different loci potentially linked to POF, such as PTHB1 and ADAMTS19. However, replications in independent cohorts need to be performed. GWAS studies on large cohorts of women with POF should find new candidate genes in the near future." @default.
- W1987629465 created "2016-06-24" @default.
- W1987629465 creator A5032547581 @default.
- W1987629465 creator A5072415091 @default.
- W1987629465 date "2010-05-01" @default.
- W1987629465 modified "2023-10-17" @default.
- W1987629465 title "Genome-wide association study and premature ovarian failure" @default.
- W1987629465 cites W1968046362 @default.
- W1987629465 cites W1994361406 @default.
- W1987629465 cites W1996910563 @default.
- W1987629465 cites W2005271852 @default.
- W1987629465 cites W2022385074 @default.
- W1987629465 cites W2023455695 @default.
- W1987629465 cites W2059970788 @default.
- W1987629465 cites W2066669827 @default.
- W1987629465 cites W2082536587 @default.
- W1987629465 cites W2109192557 @default.
- W1987629465 cites W2109299391 @default.
- W1987629465 cites W2110510486 @default.
- W1987629465 cites W2113547468 @default.
- W1987629465 cites W2129994886 @default.
- W1987629465 cites W2153075973 @default.
- W1987629465 cites W2159422401 @default.
- W1987629465 cites W2162488373 @default.
- W1987629465 cites W2163091895 @default.
- W1987629465 cites W4238644608 @default.
- W1987629465 doi "https://doi.org/10.1016/j.ando.2010.02.014" @default.
- W1987629465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20362963" @default.
- W1987629465 hasPublicationYear "2010" @default.
- W1987629465 type Work @default.
- W1987629465 sameAs 1987629465 @default.
- W1987629465 citedByCount "23" @default.
- W1987629465 countsByYear W19876294652012 @default.
- W1987629465 countsByYear W19876294652013 @default.
- W1987629465 countsByYear W19876294652014 @default.
- W1987629465 countsByYear W19876294652015 @default.
- W1987629465 countsByYear W19876294652016 @default.
- W1987629465 countsByYear W19876294652017 @default.
- W1987629465 countsByYear W19876294652021 @default.
- W1987629465 crossrefType "journal-article" @default.
- W1987629465 hasAuthorship W1987629465A5032547581 @default.
- W1987629465 hasAuthorship W1987629465A5072415091 @default.
- W1987629465 hasConcept C104317684 @default.
- W1987629465 hasConcept C106208931 @default.
- W1987629465 hasConcept C124942203 @default.
- W1987629465 hasConcept C134018914 @default.
- W1987629465 hasConcept C134925867 @default.
- W1987629465 hasConcept C135763542 @default.
- W1987629465 hasConcept C142870003 @default.
- W1987629465 hasConcept C153209595 @default.
- W1987629465 hasConcept C186413461 @default.
- W1987629465 hasConcept C2777395788 @default.
- W1987629465 hasConcept C30481170 @default.
- W1987629465 hasConcept C54355233 @default.
- W1987629465 hasConcept C60644358 @default.
- W1987629465 hasConcept C69991583 @default.
- W1987629465 hasConcept C86803240 @default.
- W1987629465 hasConceptScore W1987629465C104317684 @default.
- W1987629465 hasConceptScore W1987629465C106208931 @default.
- W1987629465 hasConceptScore W1987629465C124942203 @default.
- W1987629465 hasConceptScore W1987629465C134018914 @default.
- W1987629465 hasConceptScore W1987629465C134925867 @default.
- W1987629465 hasConceptScore W1987629465C135763542 @default.
- W1987629465 hasConceptScore W1987629465C142870003 @default.
- W1987629465 hasConceptScore W1987629465C153209595 @default.
- W1987629465 hasConceptScore W1987629465C186413461 @default.
- W1987629465 hasConceptScore W1987629465C2777395788 @default.
- W1987629465 hasConceptScore W1987629465C30481170 @default.
- W1987629465 hasConceptScore W1987629465C54355233 @default.
- W1987629465 hasConceptScore W1987629465C60644358 @default.
- W1987629465 hasConceptScore W1987629465C69991583 @default.
- W1987629465 hasConceptScore W1987629465C86803240 @default.
- W1987629465 hasIssue "3" @default.
- W1987629465 hasLocation W19876294651 @default.
- W1987629465 hasLocation W19876294652 @default.
- W1987629465 hasOpenAccess W1987629465 @default.
- W1987629465 hasPrimaryLocation W19876294651 @default.
- W1987629465 hasRelatedWork W1987629465 @default.
- W1987629465 hasRelatedWork W2031081696 @default.
- W1987629465 hasRelatedWork W2036505802 @default.
- W1987629465 hasRelatedWork W2328187738 @default.
- W1987629465 hasRelatedWork W2803947033 @default.
- W1987629465 hasRelatedWork W2900730647 @default.
- W1987629465 hasRelatedWork W2980450555 @default.
- W1987629465 hasRelatedWork W3082508018 @default.
- W1987629465 hasRelatedWork W3159625027 @default.
- W1987629465 hasRelatedWork W4376630277 @default.
- W1987629465 hasVolume "71" @default.
- W1987629465 isParatext "false" @default.
- W1987629465 isRetracted "false" @default.
- W1987629465 magId "1987629465" @default.
- W1987629465 workType "article" @default.