Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987645144> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1987645144 endingPage "376" @default.
- W1987645144 startingPage "367" @default.
- W1987645144 abstract "The results of this prospective study fail to confirm previously reported phenytoin suppression of lymphocyte responsiveness to mitogens. Our data show a significantly greater than expected percentage (p less than 0.0001) of patients requiring phenytoin treatment have low lymphocyte responsiveness to mitogens prior to phenytoin therapy. Analysis of changes in each individual's response during phenytoin treatment as compared with their pre-phenytoin responses shows a consistent trend to increased responsiveness to concanavalin A, pokeweed mitogen, and to a suboptimal concentration of phytohemagglutinin. This trend was most pronounced for patients whose serum IgA concentration was decreased while taking phenytoin, whereas there was no such trend for individuals whose serum IgA levels were not decreased. This phenomenon was not related to neurological disease classification. Phenytoin added directly to lymphocyte cultures depressed lymphocyte responses to all mitogens in a small (less than 20%) but significant degree, confirming similar in vitro studies by other investigators. Because of limited serum proteins for phenytoin binding in culture medium, these in vitro studies have little application to possible phenytoin effects on lymphocytes of patients taking it to prevent seizures. Thus, the suggestion that phenytoin causes depressed lymphocyte responses to mitogens in epileptic patients appears unwarranted." @default.
- W1987645144 created "2016-06-24" @default.
- W1987645144 creator A5010073416 @default.
- W1987645144 creator A5052820409 @default.
- W1987645144 creator A5061509642 @default.
- W1987645144 creator A5080912578 @default.
- W1987645144 date "1982-08-01" @default.
- W1987645144 modified "2023-10-18" @default.
- W1987645144 title "Phenytoin Influence on Human Lymphocyte Mitogen Response: A Prospective Study of Epileptic and Nonepileptic Patients" @default.
- W1987645144 cites W1982039936 @default.
- W1987645144 cites W2036692021 @default.
- W1987645144 cites W2040721490 @default.
- W1987645144 cites W2062709711 @default.
- W1987645144 cites W2071859658 @default.
- W1987645144 cites W2076879297 @default.
- W1987645144 cites W2090928487 @default.
- W1987645144 cites W2093933360 @default.
- W1987645144 cites W2204475770 @default.
- W1987645144 cites W2330911811 @default.
- W1987645144 cites W4236688676 @default.
- W1987645144 doi "https://doi.org/10.1111/j.1528-1157.1982.tb05422.x" @default.
- W1987645144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7094904" @default.
- W1987645144 hasPublicationYear "1982" @default.
- W1987645144 type Work @default.
- W1987645144 sameAs 1987645144 @default.
- W1987645144 citedByCount "19" @default.
- W1987645144 crossrefType "journal-article" @default.
- W1987645144 hasAuthorship W1987645144A5010073416 @default.
- W1987645144 hasAuthorship W1987645144A5052820409 @default.
- W1987645144 hasAuthorship W1987645144A5061509642 @default.
- W1987645144 hasAuthorship W1987645144A5080912578 @default.
- W1987645144 hasConcept C118552586 @default.
- W1987645144 hasConcept C126322002 @default.
- W1987645144 hasConcept C134018914 @default.
- W1987645144 hasConcept C19869320 @default.
- W1987645144 hasConcept C202751555 @default.
- W1987645144 hasConcept C203014093 @default.
- W1987645144 hasConcept C2775858608 @default.
- W1987645144 hasConcept C2777761686 @default.
- W1987645144 hasConcept C2778186239 @default.
- W1987645144 hasConcept C2778337148 @default.
- W1987645144 hasConcept C2781005381 @default.
- W1987645144 hasConcept C55493867 @default.
- W1987645144 hasConcept C71924100 @default.
- W1987645144 hasConcept C86803240 @default.
- W1987645144 hasConceptScore W1987645144C118552586 @default.
- W1987645144 hasConceptScore W1987645144C126322002 @default.
- W1987645144 hasConceptScore W1987645144C134018914 @default.
- W1987645144 hasConceptScore W1987645144C19869320 @default.
- W1987645144 hasConceptScore W1987645144C202751555 @default.
- W1987645144 hasConceptScore W1987645144C203014093 @default.
- W1987645144 hasConceptScore W1987645144C2775858608 @default.
- W1987645144 hasConceptScore W1987645144C2777761686 @default.
- W1987645144 hasConceptScore W1987645144C2778186239 @default.
- W1987645144 hasConceptScore W1987645144C2778337148 @default.
- W1987645144 hasConceptScore W1987645144C2781005381 @default.
- W1987645144 hasConceptScore W1987645144C55493867 @default.
- W1987645144 hasConceptScore W1987645144C71924100 @default.
- W1987645144 hasConceptScore W1987645144C86803240 @default.
- W1987645144 hasIssue "4" @default.
- W1987645144 hasLocation W19876451441 @default.
- W1987645144 hasLocation W19876451442 @default.
- W1987645144 hasOpenAccess W1987645144 @default.
- W1987645144 hasPrimaryLocation W19876451441 @default.
- W1987645144 hasRelatedWork W1942185150 @default.
- W1987645144 hasRelatedWork W1987645144 @default.
- W1987645144 hasRelatedWork W1990620909 @default.
- W1987645144 hasRelatedWork W1997681068 @default.
- W1987645144 hasRelatedWork W2010152717 @default.
- W1987645144 hasRelatedWork W2042784779 @default.
- W1987645144 hasRelatedWork W2074837210 @default.
- W1987645144 hasRelatedWork W2130964140 @default.
- W1987645144 hasRelatedWork W2403199714 @default.
- W1987645144 hasRelatedWork W2417154276 @default.
- W1987645144 hasVolume "23" @default.
- W1987645144 isParatext "false" @default.
- W1987645144 isRetracted "false" @default.
- W1987645144 magId "1987645144" @default.
- W1987645144 workType "article" @default.