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- W1987647039 abstract "Little is known about the signaling mechanisms that determine the highly regular patterning of intestinal epithelium into crypts and villi. Proper patterning of the gastrointestinal tract requires signaling interactions between gut epithelium and adjacent mesoderm. In a study of transgenic mice reported in the journal Science, a team from the Netherlands Institute for Developmental Biology and the University of Amsterdam show that the expression of bone morphogenetic protein (BMP) occurs exclusively in the intravillus mesenchyme and is a critical factor in mesenchymal-epithelial communication. The authors report that BMP appears critical in maintaining the intestinal crypt-villus axis, as inhibition of BMP signaling by results in the formation of numerous ectopic crypt units at right angles to the normal axis. They note that these intestinal abnormalities “phenocopy the intestinal histopathology of patients with the cancer predisposition syndrome juvenile polyposis ( JP), including the frequent occurrence of intraepithelial neoplasia. Many JP cases are known to harbor mutations in BMP pathway genes.” “We propose that inactivating mutations in BMP pathway components primarily affect the perception of mesenchymal BMP signals by epithelial cells. BMP signaling delimits ectopic crypt induction once the orthotopic structures have been specified. With loss of these inhibitory signals, the epithelial cells proceed to establish ectopic crypts, ultimately leading to the growth of juvenile polyps and to neoplasia.” For further details, see Science 2004;303:1684–1686." @default.
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- W1987647039 date "2004-06-01" @default.
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- W1987647039 title "Role of BMP signaling during intestine development and function" @default.
- W1987647039 doi "https://doi.org/10.1053/j.gastro.2004.04.067" @default.
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