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• W1987659834 startingPage "181" @default.
• W1987659834 abstract "Tissue attachment to substratum surfaces is of central importance to the in vivo performance of prosthetic implant materials. It is not yet understood why connective tissue does not attach to the surface of silicone or any other polymeric material. Recently the authors have conclusively demonstrated that micro-range surface roughness modifies cellular responses in cell culture and modifies biocompatibility and tissue attachment in vivo significantly. In order to better understand the basic interactions between living cells or tissues on one hand and man-made substratum surfaces on the other hand, the germane literature is reviewed here. Cells adhere to substratum surfaces mainly through focal adhesions which are a complex of intracellular transmembrane and extracellular proteins. Adhesion is facilitated and modified by proteins adsorbed to the substratum surface. Protein adsorption in turn is modified by the underlying substratum surface properties including surface chemistry, charge, and free energy. When silicone and other polymeric implants having well-defined surface topographic features including pores, pillars, or grooves were implanted, the tissue response to these implants was strongly influenced by the dimensions of these features as well as by other geometric details. Highest biocompatibility along with tissue attachment was seen when topographic features had dimensions of 1-3 microns and a uniform distribution. Cell culture studies revealed that topographic features affect cellular alignment, direction of proliferation, cellular attachment, growth rate, metabolism, and cytoskeletal arrangement. Since discontinuities or curvatures associated with topographic features may represent local changes in surface free energy, it is hypothesized that these discontinuities trigger changes in protein adsorption, protein configuration, and cellular response." @default.
• W1987659834 created "2016-06-24" @default.
• W1987659834 creator A5057943344 @default.
• W1987659834 creator A5087972603 @default.
• W1987659834 date "1996-01-01" @default.
• W1987659834 modified "2023-10-10" @default.
• W1987659834 title "The influence of micro-topography on cellular response and the implications for silicone implants" @default.
• W1987659834 cites W129746652 @default.
• W1987659834 cites W1514969751 @default.
• W1987659834 cites W1554006760 @default.
• W1987659834 cites W1556261928 @default.
• W1987659834 cites W1565512673 @default.
• W1987659834 cites W1580675778 @default.
• W1987659834 cites W171910026 @default.
• W1987659834 cites W1806064940 @default.
• W1987659834 cites W1831218435 @default.
• W1987659834 cites W1831820810 @default.
• W1987659834 cites W1855561741 @default.
• W1987659834 cites W1869725238 @default.
• W1987659834 cites W1899409826 @default.
• W1987659834 cites W1916984064 @default.
• W1987659834 cites W1948887717 @default.
• W1987659834 cites W1959250237 @default.
• W1987659834 cites W1964088801 @default.
• W1987659834 cites W1964350332 @default.
• W1987659834 cites W1967589959 @default.
• W1987659834 cites W1969361987 @default.
• W1987659834 cites W1970217772 @default.
• W1987659834 cites W1970918329 @default.
• W1987659834 cites W1972617359 @default.
• W1987659834 cites W1979268896 @default.
• W1987659834 cites W1981265109 @default.
• W1987659834 cites W1982753921 @default.
• W1987659834 cites W1986315323 @default.
• W1987659834 cites W1987568997 @default.
• W1987659834 cites W1987628024 @default.
• W1987659834 cites W1988790582 @default.
• W1987659834 cites W1989504647 @default.
• W1987659834 cites W1991738124 @default.
• W1987659834 cites W1991819046 @default.
• W1987659834 cites W1993034583 @default.
• W1987659834 cites W1994972999 @default.
• W1987659834 cites W1996001348 @default.
• W1987659834 cites W1997596842 @default.
• W1987659834 cites W1999794993 @default.
• W1987659834 cites W2003352408 @default.
• W1987659834 cites W2006878196 @default.
• W1987659834 cites W2010833818 @default.
• W1987659834 cites W2013381560 @default.
• W1987659834 cites W2014094627 @default.
• W1987659834 cites W2015237158 @default.
• W1987659834 cites W2015391238 @default.
• W1987659834 cites W2018892227 @default.
• W1987659834 cites W2019532052 @default.
• W1987659834 cites W2021434165 @default.
• W1987659834 cites W2024424463 @default.
• W1987659834 cites W2025096823 @default.
• W1987659834 cites W2025208026 @default.
• W1987659834 cites W2027250572 @default.
• W1987659834 cites W2031778580 @default.
• W1987659834 cites W2032813359 @default.
• W1987659834 cites W2033393629 @default.
• W1987659834 cites W2035041815 @default.
• W1987659834 cites W2039455602 @default.
• W1987659834 cites W2043620957 @default.
• W1987659834 cites W2050678173 @default.
• W1987659834 cites W2052218514 @default.
• W1987659834 cites W2055054035 @default.
• W1987659834 cites W2055130628 @default.
• W1987659834 cites W2058140669 @default.
• W1987659834 cites W2058170261 @default.
• W1987659834 cites W2060250773 @default.
• W1987659834 cites W2063191910 @default.
• W1987659834 cites W2064986267 @default.
• W1987659834 cites W2069271003 @default.
• W1987659834 cites W2069324624 @default.
• W1987659834 cites W2075149022 @default.
• W1987659834 cites W2079235642 @default.
• W1987659834 cites W2084412463 @default.
• W1987659834 cites W2085516239 @default.
• W1987659834 cites W2086277592 @default.
• W1987659834 cites W2086542322 @default.
• W1987659834 cites W2088703323 @default.
• W1987659834 cites W2089237999 @default.
• W1987659834 cites W2098799101 @default.
• W1987659834 cites W2102533478 @default.
• W1987659834 cites W2103725270 @default.
• W1987659834 cites W2106532239 @default.
• W1987659834 cites W2112093320 @default.
• W1987659834 cites W2118992386 @default.
• W1987659834 cites W2128644013 @default.
• W1987659834 cites W2128690724 @default.
• W1987659834 cites W2134734946 @default.
• W1987659834 cites W2136445687 @default.
• W1987659834 cites W2137823930 @default.
• W1987659834 cites W2139666587 @default.
• W1987659834 cites W2140079145 @default.
• W1987659834 cites W2148885060 @default.

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