FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987668975> ?p ?o ?g. }

• W1987668975 endingPage "1273" @default.
• W1987668975 startingPage "1267" @default.
• W1987668975 abstract "The role of endotoxin in alcohol-induced liver damage is well recognized. How pre-exposure to endotoxin might affect alcohol injury is not known. We herein studied the effect of endotoxin pretreatment on hepatic stellate cell (HSC) response to ethanol and acetaldehyde.Rat HSC (CFSC-2G) were exposed to media supplemented with 1 microg/mL lipopolysaccharide (LPS). This was followed by a 24 h exposure to media containing LPS plus 50 mmol/L ethanol or 175 micromol/L acetaldehyde. Lipid peroxidation, collagen, and tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and transforming growth factor (TGF)-beta1 secretion were determined at the end of both periods of exposure.Lipopolysaccharide pretreatment did not modify lipid peroxidation induced by ethanol or acetaldehyde alone. Glutathione (GSH) content decreased to 4.2 +/- 0.5 and 16.3 +/- 0.8 nmol protein after exposure to ethanol or acetaldehyde alone, and decreased further with LPS pretreatment (2.4 +/- 0.2 and 2.7 +/- 0.3 nmol/mg protein, respectively). Oxidized GSH (GSSG) content increased in ethanol and acetaldehyde LPS-pretreated cells only. Collagen secretion increased to 988 +/- 82 and 1169 +/- 91 microg/10(6) cells after exposure to acetaldehyde or LPS alone. Lipopolysaccharide pretreatment enhanced collagen secretion significantly in both ethanol- and acetaldehyde-treated cells (969 +/- 56 and 1360 +/- 72 microg/10(6) cells, respectively). Interleukin-6 production increased to 288 +/- 48, 1195 +/- 86 and 247 +/- 35 pg/mL per 10(6) cells after ethanol, acetaldehyde and LPS exposure, and increased further with LPS pretreatment in ethanol-exposed cells (680 +/- 23 pg/mL 10(6) cells).Lipopolysaccharide pretreatment of HSC adds to the damage produced by ethanol and acetaldehyde by diminishing GSH content and increasing GSSG content, collagen and IL-6 secretion." @default.
• W1987668975 created "2016-06-24" @default.
• W1987668975 creator A5006698326 @default.
• W1987668975 creator A5019418134 @default.
• W1987668975 creator A5050455929 @default.
• W1987668975 creator A5053733929 @default.
• W1987668975 creator A5056670813 @default.
• W1987668975 creator A5058964464 @default.
• W1987668975 creator A5074235648 @default.
• W1987668975 creator A5085071616 @default.
• W1987668975 creator A5087369478 @default.
• W1987668975 date "2001-11-01" @default.
• W1987668975 modified "2023-10-18" @default.
• W1987668975 title "Effect of endotoxin pretreatment on hepatic stellate cell response to ethanol and acetaldehyde" @default.
• W1987668975 cites W1590457525 @default.
• W1987668975 cites W1597011288 @default.
• W1987668975 cites W1775749144 @default.
• W1987668975 cites W1974794685 @default.
• W1987668975 cites W1981990833 @default.
• W1987668975 cites W1991764274 @default.
• W1987668975 cites W1991863368 @default.
• W1987668975 cites W1993296447 @default.
• W1987668975 cites W1999795538 @default.
• W1987668975 cites W2007064404 @default.
• W1987668975 cites W2007882007 @default.
• W1987668975 cites W2014185375 @default.
• W1987668975 cites W2024903975 @default.
• W1987668975 cites W2028178959 @default.
• W1987668975 cites W2031298306 @default.
• W1987668975 cites W2034462747 @default.
• W1987668975 cites W2035851860 @default.
• W1987668975 cites W2048430659 @default.
• W1987668975 cites W2052117688 @default.
• W1987668975 cites W2062460706 @default.
• W1987668975 cites W2072989993 @default.
• W1987668975 cites W2081527168 @default.
• W1987668975 cites W2083976597 @default.
• W1987668975 cites W2110381465 @default.
• W1987668975 cites W2163720656 @default.
• W1987668975 cites W4230498270 @default.
• W1987668975 cites W4251427903 @default.
• W1987668975 cites W4253098803 @default.
• W1987668975 doi "https://doi.org/10.1046/j.1440-1746.2001.02619.x" @default.
• W1987668975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11903746" @default.
• W1987668975 hasPublicationYear "2001" @default.
• W1987668975 type Work @default.
• W1987668975 sameAs 1987668975 @default.
• W1987668975 citedByCount "30" @default.
• W1987668975 countsByYear W19876689752012 @default.
• W1987668975 countsByYear W19876689752015 @default.
• W1987668975 countsByYear W19876689752016 @default.
• W1987668975 countsByYear W19876689752017 @default.
• W1987668975 countsByYear W19876689752018 @default.
• W1987668975 countsByYear W19876689752021 @default.
• W1987668975 countsByYear W19876689752023 @default.
• W1987668975 crossrefType "journal-article" @default.
• W1987668975 hasAuthorship W1987668975A5006698326 @default.
• W1987668975 hasAuthorship W1987668975A5019418134 @default.
• W1987668975 hasAuthorship W1987668975A5050455929 @default.
• W1987668975 hasAuthorship W1987668975A5053733929 @default.
• W1987668975 hasAuthorship W1987668975A5056670813 @default.
• W1987668975 hasAuthorship W1987668975A5058964464 @default.
• W1987668975 hasAuthorship W1987668975A5074235648 @default.
• W1987668975 hasAuthorship W1987668975A5085071616 @default.
• W1987668975 hasAuthorship W1987668975A5087369478 @default.
• W1987668975 hasConcept C126322002 @default.
• W1987668975 hasConcept C134018914 @default.
• W1987668975 hasConcept C176891718 @default.
• W1987668975 hasConcept C17991360 @default.
• W1987668975 hasConcept C181199279 @default.
• W1987668975 hasConcept C185592680 @default.
• W1987668975 hasConcept C2776151105 @default.
• W1987668975 hasConcept C2777595113 @default.
• W1987668975 hasConcept C2778754761 @default.
• W1987668975 hasConcept C2780161600 @default.
• W1987668975 hasConcept C2780829032 @default.
• W1987668975 hasConcept C538909803 @default.
• W1987668975 hasConcept C55493867 @default.
• W1987668975 hasConcept C71924100 @default.
• W1987668975 hasConceptScore W1987668975C126322002 @default.
• W1987668975 hasConceptScore W1987668975C134018914 @default.
• W1987668975 hasConceptScore W1987668975C176891718 @default.
• W1987668975 hasConceptScore W1987668975C17991360 @default.
• W1987668975 hasConceptScore W1987668975C181199279 @default.
• W1987668975 hasConceptScore W1987668975C185592680 @default.
• W1987668975 hasConceptScore W1987668975C2776151105 @default.
• W1987668975 hasConceptScore W1987668975C2777595113 @default.
• W1987668975 hasConceptScore W1987668975C2778754761 @default.
• W1987668975 hasConceptScore W1987668975C2780161600 @default.
• W1987668975 hasConceptScore W1987668975C2780829032 @default.
• W1987668975 hasConceptScore W1987668975C538909803 @default.
• W1987668975 hasConceptScore W1987668975C55493867 @default.
• W1987668975 hasConceptScore W1987668975C71924100 @default.
• W1987668975 hasIssue "11" @default.
• W1987668975 hasLocation W19876689751 @default.
• W1987668975 hasLocation W19876689752 @default.
• W1987668975 hasOpenAccess W1987668975 @default.
• W1987668975 hasPrimaryLocation W19876689751 @default.

• next