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- W1987672398 abstract "The transcription factor E2A plays a crucial role in B cell development, the control of immunoglobulin gene rearrangement and expression. Here we report that in primary mouse B cells lipopolysaccharide (LPS) is able to induce the level of E2A protein by over 50-fold in days of culture. In contrast, CD40 signaling is insufficient to cause an E2A increase and can in fact prevent the LPS-mediated induction of E2A. These results suggest that E2A induction requires both proliferation and differentiation. We find that E2A protein induction is regulated post-transcriptionally since E2A mRNA is not induced by LPS. We have thus identified an important additional layer of regulation affecting the activity of E2A transcription factors." @default.
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- W1987672398 date "2000-02-01" @default.
- W1987672398 modified "2023-10-11" @default.
- W1987672398 title "Post-transcriptional regulation of E2A proteins via lipopolysaccharide and CD40 signaling" @default.
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- W1987672398 doi "https://doi.org/10.1002/1521-4141(200002)30:2<719::aid-immu719>3.0.co;2-5" @default.
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