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• W1987676265 abstract "Peripheral lymphocytes from mice have been analyzed by a combination of cell electrophoresis and size distribution analysis and the data have been processed with a computer into two-dimensional distribution patterns (fingerprints). The fingerprints of lymph node cells revealed the existence of at least three major classes of small lymphocytes. Cells with similar physical properties were found in the spleen and thoracic duct lymph. The data also allowed calculation of the quantitative ratios of the three cell types. In the normal mouse, the two electrophoretically faster cell classes represent essentially two subclasses of T cells. The quantitative ratios are here always in agreement with the known percentages of B and T cells. Lethally irradiated mice that have been reconstituted with syngeneic bone marrow or fetal liver cells often lack one of the T cell subclasses. This has two important implications. 1) It indicates that the widely used syngeneic or allogeneic bone marrow chimeras may be incomplete in respect to their T cell repertoire and that experiments with these models should be interpreted with caution. 2) The deficiency was found to correlate strictly with a deficiency in a physically defined subset of small cortical thymocytes that has been described previously. This correlation suggests strongly that the fast peripheral T cells and the “early small cortical thymocytes” represent two developmental stages of a distinct cell lineage (“early T cell lineage”), while the thymic pool of “late small cortical thymocytes” gives rise to electrophoretically slow peripheral T cells, which may be called “late T cells”. The possibility that both T cell lineages are derived from different classes of prethymic stem cells in the reconstituting stem cell preparation is discussed. The proportion of “early T cells” in the lymph nodes decreases with age. The ratio of “late” and “early T cells” is similar in the spleen and in the lymph nodes, and both cell classes contain a significant proportion of cells that are not affected by the early effects of adult thymectomy. Thus, they do not correspond to T1 and T2 cells." @default.
• W1987676265 created "2016-06-24" @default.
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• W1987676265 date "1976-11-01" @default.
• W1987676265 modified "2023-09-25" @default.
• W1987676265 title "“Early T cells” and “late T cells”; suggestive evidence for two T cell lineages with separate developmental pathways" @default.
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• W1987676265 doi "https://doi.org/10.1002/eji.1830061102" @default.
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