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• W1987676502 abstract "The greatest risk from live-attenuated vaccines is reversion to virulence. Particular concerns arise for RNA viruses, which exhibit high mutation frequencies. We examined the stability of 3 attenuation strategies for the alphavirus, Venezuelan equine encephalitis virus (VEEV): a traditional, point mutation-dependent attenuation approach exemplified by TC-83; a rationally designed, targeted-mutation approach represented by V3526; and a chimeric vaccine, SIN/TC/ZPC. Our findings suggest that the chimeric strain combines the initial attenuation of TC-83 with the greater phenotypic stability of V3526, highlighting the importance of the both initial attenuation and stability for live-attenuated vaccines." @default.
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• W1987676502 date "2011-03-09" @default.
• W1987676502 modified "2023-09-24" @default.
• W1987676502 title "Stability of RNA virus attenuation approaches" @default.
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• W1987676502 doi "https://doi.org/10.1016/j.vaccine.2011.01.055" @default.
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