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• W1987676940 abstract "To assess frequency of involvement of neural stem cell compartment (NSC) in a series of low grade (World Health Organization [WHO] grades 1/2) and high grade (WHO grades 3/4) gliomas. Initial and subsequent cranial MRI series for 80 low grade gliomas and 104 high grade gliomas treated between 2000 and 2010 at our institution were reviewed. Maximum diameter of gross disease (GTV) was measured, and involvement of NSC was documented if present. For cases not involving NSC, minimum distance from GTV to NSC and distance from NSC to center of tumor were measured. For low grade gliomas which later recurred as high grade gliomas time interval to progression was measured, and each recurrence was evaluated for involvement of NSC. Low grade tumors were stratified by histology (astrocytoma, oligodendroglioma, oligoastrocytoma, or other), tumor grade (1 vs. 2), MIB-1 proliferative status, and pattern of growth (infiltrative vs. localized). High grade tumors were stratified by histology (for grade 3 tumors: astrocytoma, oligodendroglioma, or oligoastrocytoma) and tumor grade (3 vs. 4). All tumors were stratified by maximum diameter of gross disease (≤2 cm vs. >2 cm, ≤3 cm vs. >3 cm). A total of 71.3% (57/80) of low grade tumors involved NSC at presentation. Infiltrative low grade tumors more often involved NSC than localized tumors (94.6% vs. 51.2%, RR 1.85, CI 1.58-2.12, p = 0.13), as did tumors >2 cm or >3 cm vs. smaller tumors (81.8% vs. 21.4% and 86.5% vs. 42.9%, RR 3.82 and 2.02, CI 3.24-4.4 and 1.71-2.33, p = 0.086 and 0.123, respectively). For low grade tumors, tumor grade did not predict NSC involvement (72.4% grade 2 vs. 68.2% grade 1, RR 1.06, CI 1.04-1.08, p = 0.44), nor did histology or MIB-1 proliferative status. Of the 9 high grade recurrences, all were originally grade 2, 77.8% initially involved NSC, and 88.9% of recurrences involved NSC. Ninety-nine percent (103/104) of high grade tumors involved NSC at presentation, 101/104 (97.1%) by GTV, 2/104 pts (1.9%) by edema only. Histology (for grade 3 tumors), tumor grade, and GTV diameter did not affect the rate of NSC involvement. Involvement of NSC by GTV was 90.9% (10/11) for GTV 2cm or less and 95.7% (22/23) for GTV 3cm or less. Infiltrative low grade gliomas frequently involve NSC at presentation and at time of recurrence as high grade glioma, as do de novo high grade gliomas. While tumor volume may affect the rate of NSC involvement by low grade gliomas, it has no influence on the rate of NSC involvement by high grade gliomas, supporting our hypothesis that high grade gliomas and a subset of high risk low grade gliomas arise from the NSC compartment." @default.
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• W1987676940 date "2010-11-01" @default.
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• W1987676940 title "Involvement of the Neural Stem Cell Compartment by Low and High Grade Gliomas: A Retrospective Review of 80 Low Grade and 104 High Grade Tumors" @default.
• W1987676940 doi "https://doi.org/10.1016/j.ijrobp.2010.07.672" @default.
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