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- W1987682302 abstract "Lidoflazine is a drug that was developed by the Janssen Research Laboratories (Janssen Pharmaceutics, Beerse, Belgium) several decades ago but never became available on the international market. It has strong nucleoside transport inhibitory properties and can be classified as an ARA or adenosine regulating agent. 1 Recently, there has been increasing interest in this type of drugs for myocardial protection, because they all enhance the tissue content of adenosine in the myocardium. Adenosine is widely known for its cardioprotective properties against ischemic damage. 2 Accumulation of adenosine in the myocardium can be obtained by prevention of its breakdown (for example, by inhibition of its transport from the myocyte to the endothelial cell where adenosine is catabolized) or by stimulating its production. The latter can be done by infusing the precursor AICA riboside (5-amino-4-imidazole carboxamide riboside). This drug is now under clinical investigation in large multicenter studies in the United States, Canada, and Europe. The study of Akpinar, Vanerman, and Wellens is interesting in so far as it demonstrates that extensive coronary bypass grafting can safely be done on the fibrillating heart using one single period of aortic crossclamping combined with lidosazine pretreatment. The clinical outcome was the same as when cardioplegia was used. However, the study does not provide scientific proof" @default.
- W1987682302 created "2016-06-24" @default.
- W1987682302 creator A5016939307 @default.
- W1987682302 date "1995-05-01" @default.
- W1987682302 modified "2023-09-30" @default.
- W1987682302 title "Requested comment concerning: Lidoflazine" @default.
- W1987682302 cites W1581028088 @default.
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- W1987682302 doi "https://doi.org/10.1016/s0022-5223(95)70331-4" @default.
- W1987682302 hasPublicationYear "1995" @default.
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