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- W1987683722 abstract "in pregnancy: management, monitoring and outcomes Sharmilee Thota, Srinivas Ketharaju, Carolyn Salafia, Aleksandr Fuks Bronx-Lebanon Hospital Center, OB/GYN, Bronx, NY, Bronx-Lebanon Hospital Center, OB/GYN, Bronx, NY, New York Methodist Hospital Cornell Presbyterian, OB/GYN, Pathology, Pediatrics, Brooklyn, NY, Queens Hospital Center, OB/GYN, Queens, NY OBJECTIVE: To examine fetal and neonatal outcomes of pregnancies complicated by isoimmunization to minor red blood cell (RBC) antigens and managed by serial antibody titer and MCA-peal systolic velocity (MCA-PSV) assessments. STUDY DESIGN: Retrospective cohort study of all patients isoimmunized to minor RBC antigens managed at Bronx-Lebanon Hospital Center, 2008-2011. Inclusion criteria: live singleton gestataion, presence of minor RBC antibodies, gestational age 24 0/7 36 0/7 weeks. Exclusion criteria: multiple gestations, Kell and major RBC antibodies, fetal malformations and chromosomal abnormalities. All patients were managed with serial antibody titer and MCA-PSV assessments. Outcome parameters were assessed: birthweight, fetal bilirubin concentration, cord gas base excess, fetal hematocrit, NICU stay duration. RESULTS: 24 patients fit study inclusion criteria. Demographic and outcome parameters are summarized in the Table below. None of the patients in the study had MCA-PSV values in the range of severe fetal anemia requiring PUBS and in-utero transfusion. None of the neonates required RBC transfusion and only 2 newborns were Coombs positive and required phototherapy. CONCLUSION: Patients with alloimmunization to minor RBC antigens and antibody titers less than critical value (1:32) do not appear to be at risk for sever fetal anemia. In those patients, serial MCA-PSV assessments do not influence management decisions and outcomes of pregnancy and forgoing such evaluation might be suitable." @default.
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- W1987683722 date "2012-01-01" @default.
- W1987683722 modified "2023-09-26" @default.
- W1987683722 title "395: Isoimmunization to minor red blood cell antigens in pregnancy: management, monitoring and outcomes" @default.
- W1987683722 doi "https://doi.org/10.1016/j.ajog.2011.10.413" @default.
- W1987683722 hasPublicationYear "2012" @default.
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