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- W1987688314 abstract "The anticonvulsant action of the new anticonvulsant drug γ-vinyl-GABA (GVG) is obviously mediated by elevation of the concentration of GABA in the brain. The effect of GVG administration on other transmitter systems is not fully known in humans. We studied the possible interactions of GVG administration with peptidergic systems. Included in this study were 67 patients with complex partial epilepsy (CPS). The first CSF sample was taken before GVG administration. The second CSF sample was taken after 3 months of GVG treatment (3 g/day). Thereafter half of the responders (50% decrease in seizure frequency or clear improvement in global performance) received 3 g/day and the other half received 1.5 g/day for the next three months, after which the third CSF sample was taken. Somatostatin 9SLI), β-endorphin (β-EP), and prolactin (PROL) levels in CSF were measured by radioimmunoassay. Total GABA (tGABA) and GVG levels in CSF were measured by high performance liquid chromatography. After 3 months of GVG treatment there was a slight increase in the β-EP (p=0.027, Student's paired t-test), which was not found after 6 months of GVG administration. Both SLI and PROL were stable during the study. Peptide levels were not connected to the clinical response to GVG, GVG dosage, or to tGABA levels in the CSF. In conclusion, the elevation of GABA levels in the brain during GVG treatment apparently does not induce long-term interactions with the peptidergic systems studied." @default.
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- W1987688314 date "1987-04-01" @default.
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- W1987688314 title "Somatostatin, β-endorphin, and prolactin levels in human cerebrospinal fluid during the γ-vinyl-GABA treatment of patients with complex partial epilepsy" @default.
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- W1987688314 doi "https://doi.org/10.1016/0143-4179(87)90038-2" @default.
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