FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987691704> ?p ?o ?g. }

• W1987691704 endingPage "e100798" @default.
• W1987691704 startingPage "e100798" @default.
• W1987691704 abstract "Background Tacrolimus (TAC)-induced pancreatic islet injury is one of the important causes of new-onset diabetes in transplant recipients. This study was performed to evaluate whether a dipeptidyl peptidase IV (DPP IV) inhibitor is effective in improving TAC-induced diabetes mellitus by reducing pancreatic islet injury. Methods Rats were treated with TAC (1.5 mg/kg, subcutaneously) and the DPP IV inhibitor MK-0626 (10 or 20 mg/kg, oral gavage) for 4 weeks. The effect of MK-0626 on TAC-induced diabetes was evaluated by assessing pancreatic islet function, histopathology. TAC-induced incretin dysfunction was also examined based on active glucagon-like peptide-1 (GLP-1) levels in the serum after glucose loading. The protective effect of MK-0626 was evaluated by measuring markers of oxidative stress, oxidative resistance, and apoptosis. To determine whether enhanced GLP-1 signaling is associated with these protective effects, we measured the expression of the GLP-1 receptor (GLP-1R) and the effect of the GLP-1 analog exendin-4 on cell viability and oxidative stress in isolated islets. Results MK-0626 treatment attenuated TAC-induced pancreatic islet dysfunction and islet morphology. TAC treatment led to a defect in active GLP-1 secretion; however, MK-0626 reversed these effects. TAC treatment increased the level of 8-hydroxy-2′-deoxyguanosine (8-OHdG), the number of apoptotic death, and the level of active caspase-3, and decreased the level of manganese superoxide dismutase and heme oxygenase-1; MK-0626 treatment reversed these changes. MK-0626 treatment restored the expression of GLP-1R, and direct administration of exendin-4 to isolated islets reduced TAC-induced cell death and 8-OHdG expression. Conclusions The DPP IV inhibitor MK-0626wasan effective antidiabetic agent that exerted antioxidative and antiapoptotic effects via enhanced GLP-1 signaling in TAC-induced diabetics." @default.
• W1987691704 created "2016-06-24" @default.
• W1987691704 creator A5032494492 @default.
• W1987691704 creator A5036588164 @default.
• W1987691704 creator A5037586182 @default.
• W1987691704 creator A5041131049 @default.
• W1987691704 creator A5051201985 @default.
• W1987691704 creator A5052045527 @default.
• W1987691704 creator A5052438827 @default.
• W1987691704 creator A5090843507 @default.
• W1987691704 date "2014-06-24" @default.
• W1987691704 modified "2023-10-15" @default.
• W1987691704 title "Dipeptidyl Peptidase IV Inhibitor MK-0626 Attenuates Pancreatic Islet Injury in Tacrolimus-Induced Diabetic Rats" @default.
• W1987691704 cites W1566154831 @default.
• W1987691704 cites W1968647483 @default.
• W1987691704 cites W1971892177 @default.
• W1987691704 cites W1977179808 @default.
• W1987691704 cites W1979632477 @default.
• W1987691704 cites W1980355899 @default.
• W1987691704 cites W1990267967 @default.
• W1987691704 cites W1995347902 @default.
• W1987691704 cites W1996735932 @default.
• W1987691704 cites W2004808003 @default.
• W1987691704 cites W2018793219 @default.
• W1987691704 cites W2018824646 @default.
• W1987691704 cites W2018913177 @default.
• W1987691704 cites W2020543244 @default.
• W1987691704 cites W2024369575 @default.
• W1987691704 cites W2026265777 @default.
• W1987691704 cites W2031432327 @default.
• W1987691704 cites W2048453661 @default.
• W1987691704 cites W2052631682 @default.
• W1987691704 cites W2058445078 @default.
• W1987691704 cites W2065097998 @default.
• W1987691704 cites W2071472708 @default.
• W1987691704 cites W2073779484 @default.
• W1987691704 cites W2076450209 @default.
• W1987691704 cites W2079847644 @default.
• W1987691704 cites W2083473802 @default.
• W1987691704 cites W2083823258 @default.
• W1987691704 cites W2104610836 @default.
• W1987691704 cites W2107837156 @default.
• W1987691704 cites W2117410359 @default.
• W1987691704 cites W2120650956 @default.
• W1987691704 cites W2140980725 @default.
• W1987691704 cites W2153625048 @default.
• W1987691704 cites W2164875000 @default.
• W1987691704 cites W2166051277 @default.
• W1987691704 cites W2171947907 @default.
• W1987691704 cites W2319109068 @default.
• W1987691704 doi "https://doi.org/10.1371/journal.pone.0100798" @default.
• W1987691704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4069160" @default.
• W1987691704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24959755" @default.
• W1987691704 hasPublicationYear "2014" @default.
• W1987691704 type Work @default.
• W1987691704 sameAs 1987691704 @default.
• W1987691704 citedByCount "22" @default.
• W1987691704 countsByYear W19876917042015 @default.
• W1987691704 countsByYear W19876917042016 @default.
• W1987691704 countsByYear W19876917042017 @default.
• W1987691704 countsByYear W19876917042018 @default.
• W1987691704 countsByYear W19876917042019 @default.
• W1987691704 countsByYear W19876917042021 @default.
• W1987691704 countsByYear W19876917042022 @default.
• W1987691704 countsByYear W19876917042023 @default.
• W1987691704 crossrefType "journal-article" @default.
• W1987691704 hasAuthorship W1987691704A5032494492 @default.
• W1987691704 hasAuthorship W1987691704A5036588164 @default.
• W1987691704 hasAuthorship W1987691704A5037586182 @default.
• W1987691704 hasAuthorship W1987691704A5041131049 @default.
• W1987691704 hasAuthorship W1987691704A5051201985 @default.
• W1987691704 hasAuthorship W1987691704A5052045527 @default.
• W1987691704 hasAuthorship W1987691704A5052438827 @default.
• W1987691704 hasAuthorship W1987691704A5090843507 @default.
• W1987691704 hasBestOaLocation W19876917041 @default.
• W1987691704 hasConcept C126322002 @default.
• W1987691704 hasConcept C134018914 @default.
• W1987691704 hasConcept C156490143 @default.
• W1987691704 hasConcept C165220095 @default.
• W1987691704 hasConcept C181199279 @default.
• W1987691704 hasConcept C185592680 @default.
• W1987691704 hasConcept C2776151105 @default.
• W1987691704 hasConcept C2777180221 @default.
• W1987691704 hasConcept C2778881409 @default.
• W1987691704 hasConcept C2779280383 @default.
• W1987691704 hasConcept C2781469919 @default.
• W1987691704 hasConcept C55493867 @default.
• W1987691704 hasConcept C555293320 @default.
• W1987691704 hasConcept C71924100 @default.
• W1987691704 hasConcept C98274493 @default.
• W1987691704 hasConceptScore W1987691704C126322002 @default.
• W1987691704 hasConceptScore W1987691704C134018914 @default.
• W1987691704 hasConceptScore W1987691704C156490143 @default.
• W1987691704 hasConceptScore W1987691704C165220095 @default.
• W1987691704 hasConceptScore W1987691704C181199279 @default.
• W1987691704 hasConceptScore W1987691704C185592680 @default.
• W1987691704 hasConceptScore W1987691704C2776151105 @default.
• W1987691704 hasConceptScore W1987691704C2777180221 @default.

• next