FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1987692937> ?p ?o ?g. }

• W1987692937 endingPage "690" @default.
• W1987692937 startingPage "676" @default.
• W1987692937 abstract "Embryonic stem cell (ESC) self-renewal and differentiation are governed by a broad-ranging regulatory network. Although the transcriptional regulatory mechanisms involved have been investigated extensively, posttranscriptional regulation is still poorly understood. Here we describe a critical role of the THO complex in ESC self-renewal and differentiation. We show that THO preferentially interacts with pluripotency gene transcripts through Thoc5 and is required for self-renewal at least in part by regulating their export and expression. During differentiation, THO loses its interaction with those transcripts due to reduced Thoc5 expression, leading to decreased expression of pluripotency proteins that facilitates exit from self-renewal. THO is also important for the establishment of pluripotency, because its depletion inhibits somatic cell reprogramming and blastocyst development. Together, our data indicate that THO regulates pluripotency gene mRNA export to control ESC self-renewal and differentiation, and therefore uncover a role for this aspect of posttranscriptional regulation in stem cell fate specification." @default.
• W1987692937 created "2016-06-24" @default.
• W1987692937 creator A5005654242 @default.
• W1987692937 creator A5012278873 @default.
• W1987692937 creator A5014042900 @default.
• W1987692937 creator A5015585820 @default.
• W1987692937 creator A5048715916 @default.
• W1987692937 creator A5054019127 @default.
• W1987692937 creator A5057063911 @default.
• W1987692937 creator A5057108733 @default.
• W1987692937 creator A5058898427 @default.
• W1987692937 creator A5061137912 @default.
• W1987692937 creator A5068870075 @default.
• W1987692937 creator A5072487073 @default.
• W1987692937 creator A5077612907 @default.
• W1987692937 creator A5083404575 @default.
• W1987692937 creator A5084390957 @default.
• W1987692937 date "2013-12-01" @default.
• W1987692937 modified "2023-10-15" @default.
• W1987692937 title "The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming" @default.
• W1987692937 cites W1544636755 @default.
• W1987692937 cites W1605400213 @default.
• W1987692937 cites W1608762409 @default.
• W1987692937 cites W1652680663 @default.
• W1987692937 cites W1965428318 @default.
• W1987692937 cites W1966735041 @default.
• W1987692937 cites W1966758700 @default.
• W1987692937 cites W1971645224 @default.
• W1987692937 cites W1974365957 @default.
• W1987692937 cites W1975200987 @default.
• W1987692937 cites W1982001157 @default.
• W1987692937 cites W1983717692 @default.
• W1987692937 cites W1984537489 @default.
• W1987692937 cites W1988161053 @default.
• W1987692937 cites W1988294855 @default.
• W1987692937 cites W1995506012 @default.
• W1987692937 cites W1995547197 @default.
• W1987692937 cites W1995842607 @default.
• W1987692937 cites W1997183879 @default.
• W1987692937 cites W2000734570 @default.
• W1987692937 cites W2002881421 @default.
• W1987692937 cites W2004280138 @default.
• W1987692937 cites W2016625616 @default.
• W1987692937 cites W2017050785 @default.
• W1987692937 cites W2024551920 @default.
• W1987692937 cites W2026780397 @default.
• W1987692937 cites W2027463491 @default.
• W1987692937 cites W2030978639 @default.
• W1987692937 cites W2035047647 @default.
• W1987692937 cites W2036454804 @default.
• W1987692937 cites W2037038996 @default.
• W1987692937 cites W2038143829 @default.
• W1987692937 cites W2044731579 @default.
• W1987692937 cites W2048085228 @default.
• W1987692937 cites W2053490054 @default.
• W1987692937 cites W2060613703 @default.
• W1987692937 cites W2064906046 @default.
• W1987692937 cites W2067877852 @default.
• W1987692937 cites W2073424121 @default.
• W1987692937 cites W2076091831 @default.
• W1987692937 cites W2088128367 @default.
• W1987692937 cites W2090260381 @default.
• W1987692937 cites W2093923075 @default.
• W1987692937 cites W2097693457 @default.
• W1987692937 cites W2101543197 @default.
• W1987692937 cites W2105901782 @default.
• W1987692937 cites W2107575419 @default.
• W1987692937 cites W2108241558 @default.
• W1987692937 cites W2108317381 @default.
• W1987692937 cites W2109250023 @default.
• W1987692937 cites W2110015307 @default.
• W1987692937 cites W2120199266 @default.
• W1987692937 cites W2122215608 @default.
• W1987692937 cites W2124486107 @default.
• W1987692937 cites W2125987139 @default.
• W1987692937 cites W2133657481 @default.
• W1987692937 cites W2135792754 @default.
• W1987692937 cites W2141602707 @default.
• W1987692937 cites W2150098952 @default.
• W1987692937 cites W2152107721 @default.
• W1987692937 cites W2157253966 @default.
• W1987692937 cites W2159733516 @default.
• W1987692937 cites W2162716784 @default.
• W1987692937 cites W2163092257 @default.
• W1987692937 cites W2170340771 @default.
• W1987692937 cites W2175853567 @default.
• W1987692937 doi "https://doi.org/10.1016/j.stem.2013.10.008" @default.
• W1987692937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3962795" @default.
• W1987692937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24315442" @default.
• W1987692937 hasPublicationYear "2013" @default.
• W1987692937 type Work @default.
• W1987692937 sameAs 1987692937 @default.
• W1987692937 citedByCount "80" @default.
• W1987692937 countsByYear W19876929372014 @default.
• W1987692937 countsByYear W19876929372015 @default.
• W1987692937 countsByYear W19876929372016 @default.
• W1987692937 countsByYear W19876929372017 @default.
• W1987692937 countsByYear W19876929372018 @default.

• next