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- W1987694740 abstract "A transdermal eyelid delivery system for treating ocular diseases (eye-stick) has been developed. Ketotifen fumarate (KT) was used as a model drug. An in vivo study using rabbits showed that the eye-stick device maintained a constant conjunctival concentration of the drug for an extended period of time, which was equivalent or higher than the therapeutic level following eye drop administration. Moreover, the conjunctival concentration after eye-stick application was well predicted using the physicochemical parameters, diffusion coefficient and partition coefficient, obtained from in vitro hairless mouse skin permeation experiments." @default.
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- W1987694740 date "2007-01-01" @default.
- W1987694740 modified "2023-10-16" @default.
- W1987694740 title "Development of a Stick-Type Transdermal Eyelid Delivery System of Ketotifen Fumarate for Ophthalmic Diseases" @default.
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- W1987694740 doi "https://doi.org/10.1248/cpb.55.1002" @default.
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