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- W1987695764 abstract "The intraventricular infusion of 5 μl of physiological solution in which the concentration of calcium ions was adjusted from 1.26 mM to 151.2 mM caused spontaneous feeding and drinking in the satiated rat. The ingestive response was observed both when pellets and water freely available, in which case food consumption exhibited a dose-response relationship increasing with the millimolarity of calcium in the infusate, and when operant responses at FR 2 or FR 10 were required for food reward. The rate of bar pressing by an animal at these two schedules of reinforcement did not differ from that observed when the same animal was deprived of food and water for 23 hr. The alpha-adrenergic antagonist, phentolamine (16 μg, 32 μg), did not appreciably attenuate Ca2+-induced feeding during either ad lib or motivated conditions, though these doses drastically reduced food intake induced by the intraventricular infusion of 10 μg norepinephrine HCl. The pre-infusion of a number of additional blocking agents had variable yet consistent effects upon Ca2+-induced feeding; hexamethonium (8 μg, 25 μg), propranolol (6 μg, 28 μg) and methysergide (8 μg) each caused a statistically significant enhancement in the magnitude of the Ca2+ response while atropine (6 μg, 15 μg) significantly attenuated feeding after Ca2+. This suggests an interaction between a number of pharmacologically distinct fiber pathways that may mediate the Ca2+ feeding response. The modulation of feeding by Ca2+ ions supports an ionic theory for the regulation of body weight in the rat, in which neurons that are involved in ingestive responses and which pass through the hypothalamus and other structures along the ventricular lumen are selectively sensitive to the concentration of calcium in the extracellular fluid." @default.
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- W1987695764 date "1973-09-01" @default.
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- W1987695764 title "Action of excess calcium ions in the brain on motivated feeding in the rat: Attenuation by pharmacological antagonists" @default.
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- W1987695764 doi "https://doi.org/10.1016/0091-3057(73)90082-8" @default.
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