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- W1987697773 abstract "A method of 6-[18F]fluoro-l-3,4-dihydroxyphenylalanine (6-[18F]FDOPA) synthesis suitable for the routine production in human PET studies is described. Direct fluorination of l-3-(3-hydroxy-4-pivaloyloxyphenyl)alanine with acetyl [18F]hypofluorite in acetic acid showed the preferable regioselectivity for 6-[18F]FDOPA to its 2- and 5-fluoro isomers. The HCl-hydrolysis of the reaction mixture followed by HPLC separation using the buffered physiological saline as an eluting solution, gave a sterile and apyrogenic 6-[18]FDOPA injection for clinical studies: decay-corrected radiochemical yields of 15–21% based on acetyl [18F]hypofluorite, radiochemical purity of >97% and preparation time of 60 min." @default.
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- W1987697773 date "1993-04-01" @default.
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- W1987697773 title "Electrophilic synthesis of 6-[18F]fluoro-l-dopa: Use of 4-O-pivaloyl-l-dopa as a suitable precursor for routine production" @default.
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- W1987697773 doi "https://doi.org/10.1016/0969-8043(93)90144-y" @default.
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